[[(5-Bromothien-2-yl)sulfonyl](methyl)amino]-acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [[(5-Bromothien-2-yl)sulfonyl](methyl)amino]-acetic acid
• 英文别名: 2-[(5-bromothiophen-2-yl)sulfonyl-methylamino]acetic acid
• 化学式: C₇H₈BrNO₄S₂
• mdl: MFCD03834409
• 分子量: 314.2
• InChiKey: YGQMCSUBRSQODB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LE TRAITEMENT DE LA DOULEUR ET D'AUTRES MALADIES
  申请人：AQUILUS PHARMACEUTICALS INC

  公开号：WO2010075287A2

  公开（公告）日：2010-07-01

  The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of MMP inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP inhibitors for the treatment of pain and other diseases such as cancer. Additionally, the present invention relates to methods for treating pain in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.