2-Phenylpyrrolin-5-carbonsaeure | 802258-88-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Phenylpyrrolin-5-carbonsaeure
• 英文别名: 2-Phenyl-Δ¹-pyrrolin-carbonsaeure-5；5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid；5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid
• CAS: 802258-88-4
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: BNIFQPHOXAQFQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SMALL MOLECULE COMPOUNDS AS BROAD-SPECTRUM INHIBITORS OF METALLO-BETA-LACTAMASES
  申请人：Song Yongcheng

  公开号：US20120329842A1

  公开（公告）日：2012-12-27

  The present invention concerns methods and/or compositions for treatment and/or prevention of bacterial infection wherein the bacteria has at least one metallo-β-lactamase. The bacteria are provided with an inhibitor of the metallo-β-lactamase, for example in conjunction with an antibiotic that targets the bacteria. The bacteria may be a drug-resistant strain or susceptible to becoming a drug-resistant strain. In specific embodiments, the bacteria is Pseudomonas or Acinetobacter spp.