D-山梨糖醇单硬脂酸酯 | 26836-47-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: D-山梨糖醇单硬脂酸酯
• 英文名称: sorbitan monostearate
• 英文别名: D-Glucitol monostearate；[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl] octadecanoate
• CAS: 26836-47-5
• 化学式: C₂₄H₄₈O₇
• 分子量: 448.641
• InChiKey: KEFRSFBGIAUBNZ-CBJLPSGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  山梨醇 、 硬脂酸 在 lipase Candida sp. 99–125 作用下， 以 水 、 叔丁醇 为溶剂， 生成 [(2R,3R,4R,5S)-2,3,4,5,6-pentahydroxyhexyl] octadecanoate 、 D-山梨糖醇单硬脂酸酯
  参考文献：
  名称：

  Enzymatic production and functional characterization of d-sorbitol monoesters with various fatty acids

  摘要：

  Sugar fatty acid esters are surfactants that are widely used in food, cosmetics, and pharmaceutical industries. In this study, enzymatic production of o-sorbitol monoesters with various fatty acids (C10-C18) was assessed. Reactions were performed in tert-butanol at 40 degrees C, catalyzed by Candida sp. 99-125 lipase. Dissolution of the substrates was found to be the limiting step of the reaction, and hence preheating was performed to increase the solubility of D-sorbitol. Thus, the yield of D-sorbitol palmitate was increased from 734 to 31.6 mM. The results demonstrated that the specific lipase preferred long-chain fatty acids. The surface-active properties. of the products were also determined. (C) 2015 Published by Elsevier B.V.

  DOI：

  10.1016/j.catcom.2015.09.010

文献信息

• CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN
  申请人：Tam Tim Fat

  公开号：US20100016243A1

  公开（公告）日：2010-01-21

  A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.

  提供了一种制备纯结晶D-异戊氨酰-D-色氨酸的过程，包括去保护基本纯的N-叔丁氧羰基-D-异戊氨酰-D-色氨酸或其二酯的步骤，以得到基本纯的D-异戊氨酰-D-色氨酸。还提供了一种从基本纯的N-叔丁氧羰基-D-异戊氨酰-D-色氨酸制备纯D-异戊氨酰-D-色氨酸单铵盐的过程。D-异戊氨酰-D-色氨酸，铵盐（1:1）是一种稳定的药用固体。
• FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF
  申请人：Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

  公开号：EP3617186A1

  公开（公告）日：2020-03-04

  The present invention relates to a fluoroallylamine derivative and use thereof. In particular, the present invention relates to a compound as shown in Formula I, a prodrug, an isomer, an isotope-labeled compound, a solvate or a pharmaceutically acceptable salt thereof, which has VAP-1/SSAO inhibitory activity, and can be used for treating a disease associated with VAP-1/SSAO overactivity.

  本发明涉及一种氟烯丙胺衍生物及其用途。具体而言，本发明涉及一种如化学式I所示的化合物，一种前药、异构体、同位素标记化合物、溶剂合物或其药学上可接受的盐，具有VAP-1/SSAO抑制活性，并可用于治疗与VAP-1/SSAO过度活性相关的疾病。
• [EN] RENEWABLE ACRYLIC ACID PRODUCTION AND PRODUCTS MADE THEREFROM<br/>[FR] PRODUCTION D'ACIDE ACRYLIQUE RENOUVELABLE ET PRODUITS FABRIQUÉS À PARTIR DE CELUI-CI
  申请人：METABOLIX INC

  公开号：WO2013185009A1

  公开（公告）日：2013-12-12

  Processes and methods for making biobased acrylic acid products including acrylic acid, acrylic acid oligomers, acrylic acid esters, acrylic acid polymers and articles from renewable carbon resources are described herein.

  本文描述了制造基于生物的丙烯酸产品的过程和方法，包括丙烯酸、丙烯酸寡聚体、丙烯酸酯、丙烯酸聚合物以及利用可再生碳资源制成的物品。
• Haircare use of cyclic amine derivatives
  申请人：Cavezza Alexandre

  公开号：US20060193804A1

  公开（公告）日：2006-08-31

  The present invention relates to a process for treating human keratin fibers and/or the skin from which the said fibers emerge, in order to induce and/or stimulate the growth of the human keratin fibers and/or to stop their loss and/or to increase their density, comprising at least the application, to the human keratin fibers and/or the skin, of a cosmetic composition comprising an effective amount of at least one piperidine derivative of general formula (I), in which: R 1 denotes a halogen or a radical chosen from a linear or branched C 1 -C 6 alkyl radical, a group OR, a group NRR′, a CF 3 group, a group NHCOR or a group CONRR′; R 2 denotes a linear or branched C 1 -C 20 alkyl or alkenyl radical, the hydrocarbon-based chain of which may be optionally interrupted with a —CO— function optionally substituted with at least one group OR, COOR, NRR′, NHCOR or CONRR′ and/or with a phenyl group optionally substituted with one or more radicals R 1 ; with R and R′ denoting, independently of each other, a hydrogen atom or a linear or branched C 1 -C 6 alkyl radical, m represents an integer ranging from 0 to 5; and n represents an integer ranging from 0 to 5. or a salt or isomer thereof, leaving the said composition in contact with the keratin fibers and/or the skin from which the fibers emerge, and optionally rinsing the keratin fibers and/or the skin.

  本发明涉及一种处理人类角蛋白纤维和/或这些纤维生长的皮肤的方法，以诱导和/或刺激人类角蛋白纤维的生长和/或阻止它们的脱落和/或增加它们的密度，包括至少将含有至少一种一般式(I)的哌啶衍生物的有效量的化妆品组合物施用于人类角蛋白纤维和/或皮肤，其中： R1表示卤素或从线性或支链的C1-C6烷基基团、OR基团、NRR′基团、CF3基团、NHCOR基团或CONRR′基团中选择的基团； R2表示线性或支链的C1-C20烷基或烯基基团，其碳氢基链可以选配地被具有至少一个OR、COOR、NRR′、NHCOR或CONRR′基团和/或一个苯基（该苯基可以选择地被一个或多个基团R1取代）的—CO—功能中断，其中R和R′独立地表示氢原子或线性或支链的C1-C6烷基基团，m表示一个范围从0到5的整数；n表示一个范围从0到5的整数，或者其盐或异构体，将该组合物留在与角蛋白纤维和/或这些纤维生长的皮肤接触，然后选择性地冲洗角蛋白纤维和/或皮肤。
• Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers
  申请人：Rozot Roger

  公开号：US20070092467A1

  公开（公告）日：2007-04-26

  Oxyacetamide compounds that are inhibitors of type-1 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and which have the formula (I), or salts and/or solvates thereof: are useful for inducing and/or stimulating the growth of human keratin fibers, e.g., human head hair and/or eyelashes, and/or for retarding the loss and/or increasing the density thereof and/or for caring for and/or making up such keratin fibers.

  氧乙酰胺类化合物是类型1 15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，其化学式为（I），或其盐和/或溶剂，可用于诱导和/或刺激人类角蛋白纤维（例如，人类头发和/或睫毛）的生长，或减缓其脱落和/或增加密度和/或护理和/或美化这些角蛋白纤维。