1-[2,5-dimethyl-1-(4-methylphenyl)-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-[2,5-dimethyl-1-(4-methylphenyl)-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethanone
• 英文别名: 1-[2,5-dimethyl-1-(4-methylphenyl)pyrrol-3-yl]-2-piperidin-1-ylethanone
• 化学式: C₂₀H₂₆N₂O
• 分子量: 310.4
• InChiKey: MBPROHMRLWZAEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY
  申请人：President and Fellows of Harvard College

  公开号：EP2528911B1

  公开（公告）日：2017-10-25
• US20140275169A1
  申请人：——

  公开号：US20140275169A1

  公开（公告）日：2014-09-18
• USP14 Inhibitors for Treating or Preventing Viral Infections
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20150335652A1

  公开（公告）日：2015-11-26

  Disclosed herein are methods of treating or preventing a viral infection resulting from infection by a flavivirus, comprising administering to a subject a small molecule inhibitor of USP14, represented by Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, chemically-protected form, enantiomer or stereoisomer thereof, and pharmaceutical compositions comprising an effective amount of a compound of Formula (I) for use in the method.
• Compositions and Methods for Enhancing Proteasome Activity
  申请人：President and Fellows of Harvard College

  公开号：US20160214989A1

  公开（公告）日：2016-07-28

  Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.