3-nitro-2-benzenesulfonyl-pyridine | 188429-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-nitro-2-benzenesulfonyl-pyridine
• 英文别名: 3-Nitro-2-(phenylsulfonyl)pyridine；2-(benzenesulfonyl)-3-nitropyridine
• CAS: 188429-02-9
• 化学式: C₁₁H₈N₂O₄S
• 分子量: 264.262
• InChiKey: QBXNQOWQGUPAEO-UHFFFAOYSA-N

物化性质

• 沸点：
  481.9±30.0 °C(Predicted)
• 密度：
  1.445±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-nitro-2-(phenylthio)pyridine 在 sodium hypochlorite 、 溶剂黄146 作用下， 反应 2.0h， 生成 3-nitro-2-benzenesulfonyl-pyridine
  参考文献：
  名称：

  Green Chemical Synthesis of 2-Benzenesulfonyl-pyridine and Related Derivatives

  摘要：

  A practical synthesis of 2-benzenesulfonylpyridine, 1, is described which is a key starting material for the manufacture of an investigational new drug candidate at Eli Lilly and Company. An optimized green chemical process was developed which features a novel tandem SNAr/oxidation under mild conditions to produce the target sulfone, 1, in 86% yield and >99% purity. In addition, this novel, environmentally friendly methodology was found to be general for the synthesis of substituted aromatic pyridyl sulfides and sulfones.

  DOI：

  10.1021/op700060e

文献信息

• [EN] THIOREDOXIN REDUCTASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER<br/>[FR] INHIBITEURS DE LA THIORÉDOXINE RÉDUCTASE À UTILISER DANS LE TRAITEMENT DU CANCER
  申请人：CINDA PHARMA AB

  公开号：WO2019155086A1

  公开（公告）日：2019-08-15

  The present invention provides inhibitors of thioredoxin reductase, in particular selenium compromised thioredoxin reductase-derived apoptotic protein (SecTRAP) forming agents, for use in treating an immune cell infiltrated cancer (e.g. a T-cell infiltrated cancer) in a subject, wherein said agents stimulate an anti-cancer immune response. The present invention also provides combinations comprising a SecTRAP forming agent and other therapeutic agents for use in treating cancer.

  本发明提供了硒损害的硫代还原酶衍生的凋亡蛋白（SecTRAP）形成剂，用于治疗受免疫细胞浸润的癌症（例如T细胞浸润的癌症）的抑制剂，其中所述剂能够刺激抗癌免疫反应。本发明还提供了包含SecTRAP形成剂和其他治疗剂的组合物，用于治疗癌症。
• Pyridines and their use in the treatment of cancer
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10899710B2

  公开（公告）日：2021-01-26

  There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3, R4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.

  提供了式 (I) 的化合物或其药学上可接受的盐类，其中 L、R1、R2、R3、R4 和 n 的含义见说明，这些化合物可用于治疗癌症。
• PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER
  申请人：Arnér, Elias, Set Jenö

  公开号：EP3331858A1

  公开（公告）日：2018-06-13
• THIOREDOXIN REDUCTASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER
  申请人：Cinda Pharma AB

  公开号：EP3752151A1

  公开（公告）日：2020-12-23
• [EN] PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER<br/>[FR] PYRIDINES ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：ARNÉR ELIAS SET JENÖ

  公开号：WO2017027359A1

  公开（公告）日：2017-02-16

  There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3, R4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.