N-(2-methyl-2,3-dihydro-1H-inden-1-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: N-(2-methyl-2,3-dihydro-1H-inden-1-yl)acetamide
• 化学式: C₁₂H₁₅NO
• mdl: MFCD02103905
• 分子量: 189.25
• InChiKey: FWOODQYTHBMDLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• COMPOSITIONS CONTAINING AND METHODS OF USING 1-AMINOINDAN AND DERIVATIVES THEREOF AND PROCESS FOR PREPARING OPTICALLY ACTIVE 1-AMINOINDAN DERIVATIVES
  申请人：——

  公开号：US20020068839A1

  公开（公告）日：2002-06-06

  Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, convulsions, or seizures are treated by administering a compound of the formula: 1

  描述了1-氨基茚的新衍生物及其盐。通过将所需化合物的N-苯甲基类似物与苯丙酸对映异构体反应制备了光学活性的1-氨基茚衍生物。通过给予公式1的化合物治疗帕金森病、痴呆症、癫痫、惊厥或抽搐。
• 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF
  申请人：TEVA PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0738149A1

  公开（公告）日：1996-10-23
• EP0738149A4
  申请人：——

  公开号：EP0738149A4

  公开（公告）日：1999-10-27
• １−アミノインダン及びこれらの組成物
  申请人：テバ・ファーマシューティカル・インダストリーズ・リミテッド

  公开号：JP4782252B2

  公开（公告）日：1997-10-14
• PROPELLANE-BASED COMPOUNDS AND THE USE THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20150183787A1

  公开（公告）日：2015-07-02

  The application is directed to compounds of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R 1 -R 5 are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I, and the pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.