Lysylalanine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Lysylalanine
• 英文别名: 2-(2,6-diaminohexanoylamino)propanoic acid
• 化学式: C₉H₁₉N₃O₃
• 分子量: 217.27
• InChiKey: QOOWRKBDDXQRHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Process for preparing a B30-threonine insulin
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0017938A1

  公开（公告）日：1980-10-29

  A process for preparing a B30-threonine-insulin is described which comprises reacting a des-B30-insulin with an excess amount of a threonine derivative represented by the formulawherein Thr is L-threonine residue, R1 is hydrogen or a hydroxy-protecting group; and R2 is a carboxyl-protecting group, in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide linkages.

  描述了一种制备 B30-苏氨酸胰岛素的工艺，该工艺包括在一种专门作用于肽键中碱性氨基酸羰基的酶存在的情况下，将去 B30-胰岛素与过量的苏氨酸衍生物进行反应，其中 Thr 为 L-苏氨酸残基，R1 为氢或羟基保护基团，R2 为羧基保护基团。
• Detection of Bacteroides gingivalis
  申请人：THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

  公开号：EP0292708A2

  公开（公告）日：1988-11-30

  The present invention relates to the detection of B. gingivalis by the specific ability of B. gingivalis to hydrolyze N-carbobenzoxy-glycyl-glycyl-L-arginine-B-napthylamide deriva­tives. The present invention also relates to the use of assay systems which inhibit serum amino peptidase and enhance the detection of the B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system inhibits the serum enzyme by the use of a serum aminopeptidase inhibitor which inhibits the activity of serum aminopeptidase to a greater extent than it inhibits the activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system also increases the reliability of detection of the B. gingivalis enzyme by the use of enhancing materials which enhance the enzyme activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase to a greater extent than such materials enhance the enzyme activity of serum aminopeptidase.

  本发明涉及通过牙龈杆菌水解 N-羧基苯氧基-甘氨酰-甘氨酰-L-精氨酰-B-萘酰胺衍生物的特异性能力来检测牙龈杆菌。本发明还涉及抑制血清氨基肽酶并提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶检测能力的检测系统的使用。该检测系统通过使用血清氨基肽酶抑制剂来抑制血清酶，该抑制剂对血清氨基肽酶活性的抑制程度大于对牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶活性的抑制程度。该检测系统还通过使用增强材料提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶的酶活性，其增强程度大于此类材料对血清氨肽酶酶活性的增强程度，从而提高检测牙龈杆菌酶的可靠性。
• COMPOSITION FOR EXTERNAL APPLICATION TO SKIN
  申请人：Shiseido Company, Ltd.

  公开号：EP2123254A1

  公开（公告）日：2009-11-25

  A moisturizing agent comprising one or more than one compound selected from the group consisting of lysyl-β-alanine represented by the following general formula (1) and a salt thereof:

  一种保湿剂，包含一种或一种以上选自由下通式（1）代表的赖氨酰-β-丙氨酸及其盐组成的化合物：
• A process for enzymatic replacement of the B-30 amino acid in insulins
  申请人：DE FORENEDE BRYGGERIER A/S

  公开号：EP0045187B1

  公开（公告）日：1984-10-10
• ENZYMATIC PREPARATION OF HUMAN INSULIN
  申请人：NORDISK INSULINLABORATORIUM

  公开号：EP0085083A1

  公开（公告）日：1983-08-10