3,7-Dimethyltricyclo<6.2.2.0^1,6>dodecen-6-yl-9,10,11,12-tetracarboxylic acid dianhydride | 32251-38-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,7-Dimethyltricyclo<6.2.2.0^1,6>dodecen-6-yl-9,10,11,12-tetracarboxylic acid dianhydride
• 英文别名: 3,7-Dimethyl-11,16-dioxapentacyclo[6.5.5.0~1,6~.0~9,13~.0~14,18~]octadec-6-ene-10,12,15,17-tetrone；3,7-dimethyl-11,16-dioxapentacyclo[6.5.5.01,6.09,13.014,18]octadec-6-ene-10,12,15,17-tetrone
• CAS: 32251-38-0
• 化学式: C₁₈H₁₈O₆
• 分子量: 330.337
• InChiKey: RCLQIVSRMJYTOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,7-Dimethyltricyclo<6.2.2.0^1,6>dodecen-6-yl-9,10,11,12-tetracarboxylic acid dianhydride 在 氨 、 水 、 potassium carbonate 作用下， 以 乙酸乙酯 为溶剂， 反应 101.0h， 生成 N,N'-Bis(3-bromopropyl)-3,7-dimethyltricyclo<6.2.2.0^1,6>dodecen-6-yl-9,10,11,12-tetracarboxydiimide
  参考文献：
  名称：

  Synthesis of N,N′-bis-substituted diimides related to tricyclo[6.2.2.011,6]dodecane with an expected activity on the central nervous system

  摘要：

  Continuing our studies connected with the design of antipsychotic and anxiolytic agents with a reduced propensity toward extrapyramidal side-effects, the synthesis of new compounds related to 3,7-dimethyltricyclo [6.2.2.0(1,6)] dodecen-6-yl-9,10,11,12-tetracarboxydiimide was performed. The first result of the pharmacological screening test of two of synthesized compounds displayed their low affinity for the serotonin receptor site. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00041-x

文献信息

• Synthesis of N,N′-bis-substituted diimides related to tricyclo[6.2.2.011,6]dodecane with an expected activity on the central nervous system
  作者：Jadwiga Turlo、Slawomir Suski、Teodor Zawadowski

  DOI：10.1016/s0014-827x(98)00041-x

  日期：1998.7

  Continuing our studies connected with the design of antipsychotic and anxiolytic agents with a reduced propensity toward extrapyramidal side-effects, the synthesis of new compounds related to 3,7-dimethyltricyclo [6.2.2.0(1,6)] dodecen-6-yl-9,10,11,12-tetracarboxydiimide was performed. The first result of the pharmacological screening test of two of synthesized compounds displayed their low affinity for the serotonin receptor site. (C) 1998 Elsevier Science S.A. All rights reserved.