N-cycloheptylpropanamide | 544442-09-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-cycloheptylpropanamide
• CAS: 544442-09-3
• 化学式: C₁₀H₁₉NO
• mdl: MFCD01071288
• 分子量: 169.26
• InChiKey: KAIUIWQRPAKXBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA<br/>[FR] DÉRIVÉS DE PYRIDINE ET DE PYRIMIDINE ET LEUR UTILISATION POUR TRAITER OU PRÉVENIR LA GRIPPE, OU POUR ATTÉNUER SES SYMPTÔMES
  申请人：SAVIRA PHARMACEUTICALS GMBH

  公开号：WO2017133657A1

  公开（公告）日：2017-08-10

  Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer,or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.

  本文提供的是一种化合物，其化学式为(I)，可以是药用盐、溶剂合物、多型体、前药、共药、共晶体、互变异构体、消旋体、对映体或二对映体，或它们的混合物形式，可用于治疗、改善或预防流感。
• [EN] METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE<br/>[FR] PROCÉDÉS ET COMPOSÉS POUR LE TRAITEMENT D'UNE MALADIE GÉNÉTIQUE
  申请人：DESIGN THERAPEUTICS INC

  公开号：WO2019204781A1

  公开（公告）日：2019-10-24

  The present disclosure relates to compounds and methods for modulating the expression of bean (brain expressed, associated with NEDD4) and treating diseases and conditions in which bean plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence TGGAA; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence TGGAA; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.

  本公开涉及化合物和方法，用于调节豆腐（与NEDD4相关的脑表达）的表达，并治疗豆腐发挥积极作用的疾病和病况。该化合物可以是一种转录调节分子，具有第一末端、第二末端和寡聚骨架，其中：a）第一末端包括一种DNA结合基团，能够非共价结合到核苷酸重复序列TGGAA；b）第二末端包括结合到调节分子的蛋白结合基团，该调节分子调节包含核苷酸重复序列TGGAA的基因的表达；c）寡聚骨架包括连接第一末端和第二末端之间的连接物。
• [EN] NOVEL P2X7R ANTAGONISTS AND THEIR USE<br/>[FR] NOUVEAUX ANTAGONISTES DE P2X7R ET LEUR UTILISATION
  申请人：AFFECTIS PHARMACEUTICALS AG

  公开号：WO2012163456A1

  公开（公告）日：2012-12-06

  The present application is directed to novel P2X7R antagonists that are N- indol-3-yl-acetamide and N-azaindol-3-yl-acetamide compounds, pharmaceutical compositions comprising the same and their use for the prophylactic or therapeutic treatment of diseases mediated by P2X7R activity.

  本申请涉及新型P2X7R拮抗剂，其为N-吲哚-3-基乙酰胺和N-氮杂吲哚-3-基乙酰胺化合物，包括这些化合物的制药组合物以及它们用于预防或治疗由P2X7R活性介导的疾病的用途。
• COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
  申请人：Bartolozzi Alessandra

  公开号：US20120316173A1

  公开（公告）日：2012-12-13

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  公式（I）的化合物已被揭示。本发明的化合物与CB2受体结合，并且是激动剂、拮抗剂或反向激动剂，可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• HIV REPLICATION INHIBITOR
  申请人：Shionogi & Co., Ltd.

  公开号：EP2772480A1

  公开（公告）日：2014-09-03

  The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein, a broken line means the presence or absence of a bond; R1 is substituted or unsubstituted alkyl etc., R2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R3 is a substituted or unsubstituted aromatic carbocyclic group; R4 is a hydrogen atom etc.; R5 is a substituted or unsubstituted aromatic carbocyclic group etc.; Y is a single bond etc.; R6 is substituted or unsubstituted alkyl; R7 is -Z-R71 etc.; Z is - NR72-CO- etc.; R71 is substituted or unsubstituted alkyl etc.; R72 is a hydrogen atom etc.

  本发明提供了一种具有抗病毒作用，特别是抑制艾滋病毒复制作用的新型化合物，以及一种药物组合物，特别是一种抗艾滋病毒制剂。 其中，断线表示存在或不存在键；R1 是取代或未取代的烷基等、R2 是取代或未取代的烷氧基等；n 是 1 或 2；R3 是取代或未取代的芳香族碳环基团；R4 是氢原子等；R5 是取代或未取代的芳香族碳环基团等；Y 是单键等；R6 是取代或未取代的烷基；R7 是-Z-R71 等；Z 是-NR72-CO- 等；R71 是取代或未取代的烷基等；R72 是氢原子等。