D-阿拉伯糖 2,3,4,5-四乙酸酯 | 30571-56-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: D-阿拉伯糖 2,3,4,5-四乙酸酯
• 中文别名: (1,2,4-三乙酰氧基-5-氧代戊烷-3-基)乙酸酯；D-阿拉伯糖2,3,4,5-四乙酸酯
• 英文名称: arabinose 1,2,3,5-tetraacetate
• 英文别名: (2,3,4-triacetyloxy-5-oxopentyl) acetate
• CAS: 30571-56-3；3891-58-5
• 化学式: C₁₃H₁₈O₉
• 分子量: 318.281
• InChiKey: ZYPMNZKYVVSXOJ-UHFFFAOYSA-N

物化性质

• 介电常数：
  50.0（Ambient）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Anticancer compounds
  申请人：GODAVARI BIOREFINERIES LIMITED

  公开号：US11084843B2

  公开（公告）日：2021-08-10

  The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly in cancer stem cells. Particularly, the invention relates to compounds of Formula III to XIV for the treatment of cancer, such as breast and prostate cancer.

  本发明公开了用于抑制不受控制的细胞增殖，特别是癌症干细胞增殖的化合物。特别是，本发明涉及用于治疗癌症（如乳腺癌和前列腺癌）的式 III 至式 XIV 化合物。
• Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
  申请人：——

  公开号：US20030224420A1

  公开（公告）日：2003-12-04

  This invention relates to a method for separating long-term label retaining cells or stem cells. In particular, this invention relates to a method for separating long-term label retaining cells and/or stem cells from tissues or individuals and for measuring proliferation rates of long-term label retaining cells and stem cells, as well as determining clonal expansion (proliferative history) of cell lineages from the tissues of the individual. The cells may be double-labeled with a cell-lineage marking label and isotopically labeled DNA synthesis precursor prior to physical separation.

  本发明涉及一种分离长期标签保留细胞或干细胞的方法。特别是，本发明涉及一种从组织或个体中分离长期标记保留细胞和/或干细胞的方法，以及测量长期标记保留细胞和干细胞的增殖率，以及确定个体组织中细胞系的克隆扩增（增殖历史）的方法。在进行物理分离之前，可以用细胞系标记标签和同位素标记 DNA 合成前体对细胞进行双重标记。
• Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
  申请人：Hellerstein K. Marc

  公开号：US20050202406A1

  公开（公告）日：2005-09-15

  The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and confirmation of new indications for approved drugs. Screening and detection of toxic effects of compounds also can be achieved by using the methods of the invention. The methods comprise administering isotope-labeled substrates to a living system so that the label is incorporated into molecules in a manner that reveals flux rates through metabolic pathways thought to be involved in a disease. Comparisons between living systems exposed to compounds and living systems not so exposed reveals the effects of the compounds on the flux rates through the metabolic pathways. Combinations or mixtures of compounds can be systematically screened to detect unanticipated or unintended biological actions, including synergistic actions, in the same manner.

  本发明可在活体系统中对化合物进行高通量筛选，以检测未预期或意外的生物作用。本发明还能筛选、检测和确认已批准药物的新适应症。使用本发明的方法还可以筛选和检测化合物的毒性作用。这些方法包括将同位素标记的底物注入活体系统，使标记融入分子，从而揭示被认为与疾病有关的代谢途径的通量。比较暴露于化合物的活体系统和未暴露于化合物的活体系统，可以发现化合物对代谢途径通量的影响。可以用同样的方法对化合物的组合或混合物进行系统筛选，以检测意外或非预期的生物作用，包括协同作用。
• METHODS FOR COMPARING RELATIVE FLUX RATES OF TWO OR MORE BIOLOGICAL MOLECULES IN VIVO THROUGH A SINGLE PROTOCOL
  申请人：The Regents of the University of California

  公开号：EP1663319A2

  公开（公告）日：2006-06-07
• EP1663319A4
  申请人：——

  公开号：EP1663319A4

  公开（公告）日：2009-08-26