2-azaniumyl-2-(4-nitrosophenyl)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-azaniumyl-2-(4-nitrosophenyl)acetate
• 化学式: C8H8N2O3
• mdl: MFCD01860019
• 分子量: 180.16
• InChiKey: YYCNTMPHDDBZJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  92.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] BRIDGED LIPOGLYCOPEPTIDES THAT POTENTIATE THE ACTIVITY OF BETA-LACTAM ANTIBACTERIALS<br/>[FR] LIPOGLYCOPEPTIDES PONTÉS QUI POTENTIALISENT L'ACTIVITÉ DES ANTIBACTÉRIENS BÊTA-LACTAME
  申请人：MERCK SHARP & DOHME

  公开号：WO2011112441A1

  公开（公告）日：2011-09-15

  The present invention provides novel lipoglycopeptide compounds which are Type 1 signal peptidase inhibitors (SpsB). Compounds of the present invention are useful for the treatment of various bacterial related infectious diseases, particularly when used as a potentiator of a β-lactam antibiotic such as imipenem and ertapenem. Accordingly, the present invention provides a method for the treatment of bacterial related infections using the compounds described herein, either alone or in combination with a β-lactam antibiotic.