DL-Β-高甲硫氨酸

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: DL-Β-高甲硫氨酸
• 英文名称: 3-azaniumyl-5-methylsulfanylpentanoate
• 化学式: C6H13NO2S
• mdl: MFCD06205952
• 分子量: 163.24
• InChiKey: QWVNCDVONVDGDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for designing polypeptides for the nanofabrication of thin films, coatings and microcapsules by electrostatic layer-by-layer self assembly
  申请人：Louisiana Tech University Foundation

  公开号：EP2193799A1

  公开（公告）日：2010-06-09

  The invention relates to a thin film, said film comprising a plurality of layers of polypeptides, said layers of polypeptides having alternating charges, wherein at least one of said polypeptides comprises one or more amino acid sequence motifs consisting of n amino acids, at least x of which are positively charged and none is negatively charged, or at least x of which are negatively charged and none is positively charged, wherein x is greater than or equal to approximately one-half of n.

  本发明涉及一种薄膜，所述薄膜包括多层多肽，所述多肽层具有交替电荷，其中至少一种所述多肽包括由 n 个氨基酸组成的一个或多个氨基酸序列图案，其中至少 x 个带正电荷，没有一个带负电荷，或者至少 x 个带负电荷，没有一个带正电荷，其中 x 大于或等于 n 的约二分之一。
• Immunogenic compositions and methods of use
  申请人：Artificial Cell Technologies, Inc.

  公开号：EP2308900A2

  公开（公告）日：2011-04-13

  Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.

  本文公开了一种免疫原性组合物，该组合物包括由两层或多层聚电解质组成的多层膜，其中相邻层由带相反电荷的聚电解质组成。第一层聚电解质由抗原多肽组成，抗原多肽包括与一个或多个抗原决定区共价连接的一个或多个表面吸附区，其中抗原多肽和一个或多个表面吸附区具有相同的极性。免疫原组合物可用于激发脊椎动物免疫反应的方法中。
• Method for designing polypeptides for the nanofabrication of thin films, coatings, and microcapsules by electrostatic layer-by-layer self assembly
  申请人：Haynie T. Donald

  公开号：US20050069950A1

  公开（公告）日：2005-03-31

  A method for designing polypeptides for the nanofabrication of thin films, coatings, and microcapsules by ELBL for applications in biomedicine and other fields.

  一种设计多肽的方法，用于通过 ELBL 技术制造纳米薄膜、涂层和微胶囊，以应用于生物医学和其他领域。
• Method for controlling stability of nanofabricated polypeptide multilayer films, coatings, and microcapsules
  申请人：Haynie T. Donald

  公开号：US20060147543A1

  公开（公告）日：2006-07-06

  Disclosed herein is a method of controlling the stability of multilayer polypeptide films. A method of controlling the stability of a film, comprises exposing the film to an oxidizing agent or a reducing agent, wherein the film comprises a plurality of layers, the layers comprising alternating oppositely charged polypeptides, wherein a first layer comprises a first layer polypeptide and a second layer comprises a second layer polypeptide, and the first layer polypeptide comprises a sulfhydryl-containing amino acid.

  本文公开了一种控制多层多肽薄膜稳定性的方法。一种控制薄膜稳定性的方法，包括将薄膜暴露于氧化剂或还原剂中，其中薄膜包括多层，各层包括交替带相反电荷的多肽，其中第一层包括第一层多肽，第二层包括第二层多肽，第一层多肽包括含巯基的氨基酸。
• Method for design of polypeptides for nanofabrication of multilayer films, coatings, and microcapsules
  申请人：Haynie T. Donald

  公开号：US20060155482A1

  公开（公告）日：2006-07-13

  A method for designing polypeptides suitable, for example, for the nanofabrication of thin films, coatings, and microcapsules by ELBL for applications in biomedicine and other fields is described. In one embodiment, the method comprises identifying an amino acid sequence motif comprising n+1 amino acids, wherein a balance of charges of the same charge in the amino acid sequence motif is greater than or equal to one half of n; and covalently joining two or more amino acid sequence motifs having the same net charge; wherein the two or more amino acid sequence motifs are the same or different.

  本发明描述了一种设计多肽的方法，该方法适用于例如通过 ELBL 纳米制造薄膜、涂层和微胶囊，以应用于生物医学和其他领域。在一个实施方案中，该方法包括识别由 n+1 个氨基酸组成的氨基酸序列图案，其中氨基酸序列图案中相同电荷的平衡大于或等于 n 的二分之一；以及共价连接具有相同净电荷的两个或多个氨基酸序列图案；其中两个或多个氨基酸序列图案相同或不同。