DL-甲状腺氨酸纳盐 | 1491-91-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: DL-甲状腺氨酸纳盐
• 中文别名: 外消旋左旋甲状腺素钠
• 英文名称: Levothyroxine (sodium); T4 (sodium)
• CAS: 1491-91-4
• 化学式: C15H11I4NNaO4
• 分子量: 799.86
• InChiKey: BRLSOHUOWVCKNI-UHFFFAOYSA-N

物化性质

• 熔点：
  >174°C (dec.)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2922509090

文献信息

• [EN] NOVEL PROCESS FOR THE PREPARATION OF LEVOTHYROXINE SODIUM<br/>[FR] NOUVEAU PROCÉDÉ POUR LA PRÉPARATION DE LÉVOTHYROXINE SODIQUE
  申请人：AZICO PHARMACEUTICALS PRIVATE LTD

  公开号：WO2015011573A1

  公开（公告）日：2015-01-29

  The present invention provides a novel process for the preparation of highly pure Levothyroxine Sodium, i.e., (S)-2-amino-3-[4-(4-hydroxy-3, 5-diiodophenoxy)-3,5- diiodophenyl] propanoic acid sodium salt via two process intermediates viz 3,5-Diiodo L- Tyrosine copper complex and novel Bis (p-anisyl) iodonium lodide.The invention also provides levothyroxine pentahydrate free from genotoxic impurities and liothyronine levels below 0.04% wt/wt.

  该发明提供了一种新型工艺，用于制备高纯度左旋甲状腺素钠，即(S)-2-氨基-3-[4-(4-羟基-3，5-二碘苯氧基)-3,5-二碘苯基]丙酸钠盐，通过两个工艺中间体，即3,5-二碘L-酪氨酸铜络合物和新型双(对甲氧基苯基)碘化物。该发明还提供了不含基因毒性杂质的左旋甲状腺素五水合物，以及甲状腺素水平低于0.04%重量/重量。
• NOVEL PROCESS FOR THE PREPARATION OF LEVOTHYROXINE SODIUM
  申请人：AZICO BIOPHORE INDIA PRIVATE LIMITED

  公开号：US20160168076A1

  公开（公告）日：2016-06-16

  The present invention provides a novel process for the preparation of highly pure Levothyroxine Sodium, i.e., (S)-2-amino-3-[4-(4-hydroxy-3, 5-diiodophenoxy)-3,5-diiodophenyl] propanoic acid sodium salt via two process intermediates viz 3,5-Diiodo L-Tyrosine copper complex and novel Bis (p-anisyl) iodonium Iodide. The invention also provides levothyroxine pentahydrate free from genotoxic impurities and liothyronine levels below 0.04% wt/wt.

  本发明提供了一种新的方法，用于制备高度纯净的左旋甲状腺素钠，即(S)-2-氨基-3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]丙酸钠盐，通过两个过程中间体，即3,5-二碘L-酪氨酸铜络合物和新型双(对甲氧基苯基)碘化物。本发明还提供了无致突变杂质的左旋甲状腺素五水合物，且甲状腺素水平低于0.04%重量/重量。
• Drug preparations
  申请人：——

  公开号：US20020037319A1

  公开（公告）日：2002-03-28

  Semisolid, sustained-release drug delivery compositions based on hyaluronic acid and its salts, and more particularly to the manufacture and use of such compositions.

  半固态、持续释放的药物传递组合物基于透明质酸及其盐，更具体地说是关于这种组合物的制造和使用。
• Variable volume assay device and method
  申请人：E-Y LABORATORIES, INC.

  公开号：EP0246760A2

  公开（公告）日：1987-11-25

  An assay device for the detection of one or more components in a liquid sample, specifically antigens or antibodies in a biologically derived sample. The device defines a chamber (12) of variable volume which is essentially sealed except for a membrane (24) across an inlet port. The sample is placed on the exterior of the membrane (24). It is drawn to the chamber by suction created by decreasing the volume of the chamber (12). Liquid within the chamber (12) is forced out of it under internal pressure created by decreasing the chamber volume. The chamber volume can be varied by twisting of a threadedly mounted piston (16) in a body. In one embodiment, a sandwich assay for the detection of an antigen in a sample, the antigen is bound to immobilized antibody on a distinct region of the membrane and is also reacted with labeled antibody for detection. The sample is cycled through the membrane by varying the chamber volume.

  一种检测装置，用于检测液体样本中的一种或多种成分，特别是生物衍生样本中的抗原或抗体。该装置定义了一个容积可变的腔室（12），该腔室基本上是密封的，只有一个膜（24）横跨入口。样品放置在膜（24）的外部。通过减小腔室 (12) 的容积产生的吸力将样品吸入腔室。腔室 (12) 内的液体在腔室容积减小产生的内部压力作用下被挤出腔室。腔室容积可通过扭转主体中螺纹安装的活塞 (16) 来改变。在一种用于检测样品中抗原的夹心检测法中，抗原与固定在膜的不同区域上的抗体结合，并与用于检测的标记抗体反应。样品通过改变室容积循环通过膜。
• Fluorescent compound, complex, reagent, and specific binding assay employing said reagent
  申请人：DOJINDO LABORATORIES

  公开号：EP0493745A1

  公开（公告）日：1992-07-08

  A fluorescent compound, which is readily capable of forming a stable complex with a rare-earth metal ion having fluorescence with satisfactory intensity even in an aqueous system and long fluorescence lifetime when formed a complex with the rare-earth metal ion, a complex of the fluorescent compound and the rare-earth metal ion, and a labelled reagent made therefrom, together with a specific binding assay using said labelling agent. A fluorescent compound expressed by the following formula A, typically exemplified by 2,15-diaza[3,3](2,9)-1,10-phenanthrolinophane-N²,N¹⁵-diacetic acid. Formula A

  一种荧光化合物，它能很容易地与稀土金属离子形成稳定的络合物，在与稀土金属离子形成络合物时，即使在水体系中也具有令人满意的荧光强度和较长的荧光寿命，一种荧光化合物与稀土金属离子的络合物，以及由其制成的标记试剂，连同使用所述标记剂的特异性结合测定。 由下式 A 表示的荧光化合物，通常以 2,15-二氮杂[3,3](2,9)-1,10-菲咯烷-N²,N¹⁵-二乙酸为例。 式 A