endiandric acid B | 76060-33-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: endiandric acid B
• 英文别名: (E)-4-[(1S,2S,3R,6R,7R,10S,11S,12S)-7-phenyl-2-tetracyclo[8.2.1.03,12.06,11]trideca-4,8-dienyl]but-2-enoic acid
• CAS: 76060-33-8
• 化学式: C₂₃H₂₄O₂
• 分子量: 332.442
• InChiKey: OXHPUGDWCMBQGE-BKJMHZRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  endiandric acid B 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 28.0 ℃ 、90.39 kPa 条件下， 反应 1.25h， 生成 4-(6'-phenyltetracyclo<5,4,2,0^3.13,0^10.12>tridec-11'-yl)butanoic acid
  参考文献：
  名称：

  Bandaranayake, Wickramasinghe M.; Banfield, James E.; Black, David St.C., Australian Journal of Chemistry, 1982, vol. 35, # 3, p. 557 - 565

  摘要：

  DOI：
• 作为产物：
  描述：

  ((1S,1aS,2aS,5R,5aR,7aR,7bS,7cS)-5-Phenyl-1a,2,2a,5,5a,7a,7b,7c-octahydro-1H-cyclobuta[bc]acenaphthylen-1-yl)-acetonitrile 在 二异丁基氢化铝 作用下， 以 苯 为溶剂， 生成 endiandric acid B
  参考文献：
  名称：

  The endiandric acid cascade. Electrocyclizations in organic synthesis. I. Stepwise, stereocontrolled total synthesis of endiandric acids A and B

  摘要：

  DOI：

  10.1021/ja00384a077

文献信息

• Endiandric acid H and its derivatives, process for their preparation and use thereof
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040138313A1

  公开（公告）日：2004-07-15

  The invention relates to compounds of the formula (I) 1 process for their preparation starting from the plant Beilschmiedia fulva, PLA 101 037, and the use thereof for producing a medicament, in particular for the treatment of allergic disorders, of asthmatic disorders, of inflammatory concomitant symptoms of asthma and/or of diseases which can be treated by inhibiting c-maf and NFAT.

  本发明涉及式 (I) 的化合物 1 从植物 Beilschmiedia fulva、 PLA 101 037，及其用于生产药物，特别是用于治疗过敏性疾病、哮喘性疾病、哮喘的炎症伴随症状和/或可通过抑制 c-maf 和 NFAT 治疗的疾病。
• Banfield, James E.; Black, David St. C.; Collins, David J., Australian Journal of Chemistry, 1994, vol. 47, # 4, p. 587 - 608
  作者：Banfield, James E.、Black, David St. C.、Collins, David J.、Hyland, Bernard P. M.、Lee, Jeffrey J.、Pranowo, Siti Rismini

  DOI：——

  日期：——
• ENDIANDRIC ACID H DERIVATE ALS C-MAF INHIBITOREN ZUR VERWENDUNG GEGEN ASTHMA
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1529040A1

  公开（公告）日：2005-05-11
• Extracts of Cranberry and Methods of Using Thereof
  申请人：Alberte Randall S.

  公开号：US20100028469A1

  公开（公告）日：2010-02-04

  The present disclosure relates in part to extracts of cranberry ( Vaccinium macrocarpon ) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans . Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans . Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.
• US7019028B2
  申请人：——

  公开号：US7019028B2

  公开（公告）日：2006-03-28