N-{[(Prop-2-en-1-yl)oxy]carbonyl}tyrosine | 7469-28-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{[(Prop-2-en-1-yl)oxy]carbonyl}tyrosine
• 英文别名: 3-(4-hydroxyphenyl)-2-(prop-2-enoxycarbonylamino)propanoic acid
• CAS: 7469-28-5
• 化学式: C₁₃H₁₅NO₅
• mdl: MFCD21380492
• 分子量: 265.26
• InChiKey: SZXHPUSFYYGCDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ANTITHROMBOTIC COMPOUND
  申请人：Sanofi-Aventis

  公开号：EP1725577A1

  公开（公告）日：2006-11-29
• [EN] ANTITHROMBOTIC COMPOUND<br/>[FR] COMPOSE ANTITHROMBOTIQUE
  申请人：SANOFI AVENTIS

  公开号：WO2005090382A1

  公开（公告）日：2005-09-29

  The present invention relates compounds of the formula (A) oligosaccharide-spacer-GpIIb/IIIa antagonist (A), wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising four to twenty five monosaccharide units, the charge being compensated by positively charged counterions, and wherein the oligosaccharide residue is derived from an oligosaccharide which has (AT-III mediated) anti-Xa activity per se; the spacer is a bond or an essentially pharmacologically inactive linking residue; the GpIIb/IIIa antagonist is a residue mimicking the RGD and/or K(QA)GD fragment of fibrinogen, typically comprising an optionally esterified carboxylate moiety and a basic moiety located within the residue at a distance of 10-20 Å from each other; or a pharmaceutically acceptable salt thereof or a prodrug or a solvate thereof. The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombotic diseases.