diisopropyl (phenyl(o-tolyl)methyl)phosphonate | 1562508-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diisopropyl (phenyl(o-tolyl)methyl)phosphonate
• 英文别名: 1-Methyl-2-[[oxido-di(propan-2-yloxy)phosphaniumyl]-phenylmethyl]benzene；1-methyl-2-[[oxido-di(propan-2-yloxy)phosphaniumyl]-phenylmethyl]benzene
• CAS: 1562508-16-0
• 化学式: C₂₀H₂₇O₃P
• 分子量: 346.406
• InChiKey: PTLGORKAWIIJFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻甲基氯化苄 在 palladium diacetate 、 sodium t-butanolate 、 正丁基二(1-金刚烷基)膦 作用下， 反应 20.0h， 生成 diisopropyl (phenyl(o-tolyl)methyl)phosphonate
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

  摘要：

  A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).

  DOI：

  10.1021/ol5002413

文献信息

• Palladium-Catalyzed α-Arylation of Benzylic Phosphonates
  作者：Sonia Montel、Ludovic Raffier、Yuying He、Patrick J. Walsh

  DOI：10.1021/ol5002413

  日期：2014.3.7

  A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).