1-N-Dodecyl-carbamoylmethyl-piperidin-3-carboxamid | 94874-82-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-N-Dodecyl-carbamoylmethyl-piperidin-3-carboxamid
• 英文别名: 3-Carbamoyl-N-dodecyl-1-piperidineacetamide；1-[2-(dodecylamino)-2-oxoethyl]piperidine-3-carboxamide
• CAS: 94874-82-5
• 化学式: C₂₀H₃₉N₃O₂
• 分子量: 353.549
• InChiKey: GGSFBZYPHYHMTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NPC1L1 AND NPC1L1 INHIBITORS AND METHODS OF USE THEREOF
  申请人：Ioannou Yiannis

  公开号：US20090035784A1

  公开（公告）日：2009-02-05

  The present invention provides a novel gene, designated herein as “NPC1L1”, that is associated with lipid or glucose metabolism. The invention further provides the use of the NPC1L1 gene and its corresponding protein to diagnose a lipid condition in a cell or tissue and to screen for novel therapeutic compounds useful for treating lipid disorders and other NPC1L1-associated or mediated diseases or disorders. The invention further provides specific inhibitors of NPC1L1.
• METHOD FOR EXTENDING LONGEVITY USING NPC1L1 ANTAGONISTS
  申请人：Ioannou Yiannis

  公开号：US20100119525A1

  公开（公告）日：2010-05-13

  The present invention relates to a method for prolonging longevity using and NPC1L1 antagonist. The present invention also provides a method for reducing weight in an individual who consumes a high-fat diet using an NPC1L1 antagonist.