N-cyclooctylhexanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-cyclooctylhexanamide
• 化学式: C₁₄H₂₇NO
• 分子量: 225.37
• InChiKey: UOPDOLVUHFWORX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Therapeutic hyperbranched polyglycerol encapsulated biomolecules
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10668161B2

  公开（公告）日：2020-06-02

  Methods for modifying therapeutic agents such as therapeutic biomolecules, such as proteins for improved oral, rectal or transmucosal delivery, as well as compositions made using such methods and methods of administering such compositions to a subject, are disclosed. Specifically, the therapeutic agents are conjugated to hyperbranched polymers (HBPs), such as hyperbranched polyglycerol (HPG). When such conjugates are administered orally to a subject, the HBP protects the therapeutic agent from the acid environment of the stomach and protease attack in the gastro-intestinal tract, while facilitating the absorption of the therapeutic agent in the higher pH environment of the intestines. The methods and compositions are useful for the improved administration of a variety of therapeutic agents to a subject.

  本发明公开了用于改进口服、直肠或经粘膜给药的治疗剂（如治疗性生物大分子）（如蛋白质）的改性方法，以及使用此类方法制成的组合物和向受试者施用此类组合物的方法。具体来说，治疗剂与超支化聚合物（HBPs），如超支化聚甘油（HPG）共轭。向受试者口服这种共轭物时，HBP 可保护治疗剂免受胃酸环境和胃肠道蛋白酶的侵蚀，同时促进治疗剂在肠道较高 pH 值环境中的吸收。这些方法和组合物有助于改进对受试者的各种治疗剂的给药。