2-((tert-Butoxycarbonyl)amino)hexanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-((tert-Butoxycarbonyl)amino)hexanedioic acid
• 英文别名: 2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanedioic acid
• 化学式: C₁₁H₁₉NO₆
• mdl: MFCD00190782
• 分子量: 261.27
• InChiKey: QDTDLMJRZPSKDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.727
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] ENZYME INHIBITORS<br/>[FR] INHIBITEURS D'ENZYMES
  申请人：KALVISTA PHARMACEUTICALS LTD

  公开号：WO2021032933A1

  公开（公告）日：2021-02-25

  The present invention provides compounds of formula (I): Formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, Y, n, R1, R2A, R2B, R3 and *1 are as defined herein.

  本发明提供了如下式(I)的化合物：化合物组合物；在治疗中使用这些化合物；以及使用这些化合物治疗患者的方法；其中A、Y、n、R1、R2A、R2B、R3和*1如本文所定义。
• [EN] POTENT INHIBITORS OF ASPARTATE N-ACETYL-TRANSFERASE FOR THE TREATMENT OF CANAVAN DISEASE<br/>[FR] INHIBITEURS PUISSANTS DE L'ASPARTATE N-ACÉTYL-TRANSFÉRASE POUR LE TRAITEMENT DE LA MALADIE DE CANAVAN
  申请人：UNIV TOLEDO

  公开号：WO2017172476A1

  公开（公告）日：2017-10-05

  Compounds, compositions, and methods for the treatment of Canavan disease are described.

  描述了用于治疗卡纳万病的化合物、组合物和方法。
• COMPOSITION FOR FORMING HIGHLY ADHESIVE RESIST UNDERLAYER FILM
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD

  公开号：US20150031206A1

  公开（公告）日：2015-01-29

  A composition for forming a resist underlayer film for lithography, including a polymer having a repeating structural unit of Formula (1): R 1 is a hydrogen atom or a methyl group and Q 1 is a group of Formula (2) or Formula (3): (wherein R 2 , R 3 , R 5 , and R 6 are independently a hydrogen atom or a linear or branched hydrocarbon group having a carbon atom number of 1 to 4, R 4 is a hydrogen atom or a methyl group, R 7 is a linear or branched hydrocarbon group having a carbon atom number of 1 to 6, a C 1-4 alkoxy group, a C 1-4 alkylthio group, a halogen atom, a cyano group, or a nitro group, w 1 is an integer of 0 to 3, w 2 is an integer of 0 to 2, and x is an integer of 0 to 3), and v 1 and v 2 are independently 0 or 1; and an organic solvent.

  一种用于光刻的阻抗下层膜的组合物，包括具有重复结构单元公式（1）的聚合物：其中R1是氢原子或甲基基团，Q1是公式（2）或公式（3）的基团：（其中R2、R3、R5和R6分别是具有1至4个碳原子的线性或支链烃基或氢原子，R4是氢原子或甲基基团，R7是具有1至6个碳原子的线性或支链烃基、C1-4烷氧基、C1-4烷硫基、卤素原子、氰基或硝基，w1为0至3的整数，w2为0至2的整数，x为0至3的整数），以及有机溶剂。
• THIENYLAZOLE COMPOUND AND THIENOTRIAZOLODIAZEPINE COMPOUND
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0776892A1

  公开（公告）日：1997-06-04

  Thienylazole compounds (I) and thienotriazolodiazepine compounds (II) of the formulas wherein R1 and R2 are hydrogen, halogen, C1-C5 alkyl and the like; -A=B-is -N=N- and the like; R3 and R19 are hydrogen, C1-C5 alkyl and the like; Y is -NHCO, -NHCONH-, -NHCOO- and the like; Z1 and Z2 are aryl, heteroaryl and the like; Ar is halogen-substituted phenyl and the like; and m is 0 or an integer of 1-5. The compounds of the present invention have CCK antagonistic action and gastrin antagonistic action, particularly potent antagonistic action against CCK-A receptor, and are useful as agents for the prophylaxis and treatment of central and peripheral nervous system diseases (e.g., anxiety, schizophrenia, and the like) and digestive diseases (e.g., pancreatitis, gastric ulcer, enterelcosis, irritable bowel syndrome, constipation, and the like).

  噻吩基氮唑化合物(I)和噻吩三唑并二氮杂卓化合物(II)，其式如下 其中 R1 和 R2 是氢、卤素、C1-C5 烷基和类似物；-A=B- 是-N=N- 和类似物；R3 和 R19 是氢、C1-C5 烷基和类似物；Y 是-NHCO、-NHCONH-、-NHCOO- 和类似物；Z1 和 Z2 是芳基、杂芳基和类似物；Ar 是卤素取代的苯基和类似物；m 是 0 或 1-5 的整数。 本发明的化合物具有 CCK 拮抗作用和胃泌素拮抗作用，特别是对 CCK-A 受体具有强效的拮抗作用，可作为预防和治疗中枢和周围神经系统疾病（如焦虑症、精神分裂症等）和消化系统疾病（如胰腺炎、胃溃疡、肠梗阻、肠易激综合征、便秘等）的药物。
• Potent inhibitors of aspartate N-acetyl-transferase for the treatment of Canavan disease
  申请人：The University of Toledo

  公开号：US11186541B2

  公开（公告）日：2021-11-30

  Compounds, compositions, and methods for the treatment of Canavan disease are described.

  描述了治疗卡纳万病的化合物、组合物和方法。