2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoic Acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoic Acid
• 化学式: C₉H₁₉N₅O₃
• 分子量: 245.28
• InChiKey: WVRUNFYJIHNFKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Nutrient compositions containing peptides
  申请人：CLINTEC NUTRITION COMPANY

  公开号：EP0457314A1

  公开（公告）日：1991-11-21

  Nutrient compositions comprise an aqueous solution of at least one dipeptide with an N-terminal amino acid selected from glutamine, aspargine, tyrosine, tryptophan, and aspargine. The C-terminal amino acid is alanine, glycine, tryptophan, arginine, proline or serine. The nutritional compositions contain from about 0.1 to 25.0 percent by weight of oligopeptides, preferably about 0.5 to 5.0 percent by weight.

  营养组合物包含至少一种二肽的水溶液，其 N 端氨基酸选自谷氨酰胺、天门冬氨酸、酪氨酸、色氨酸和天门冬氨酸。 C 端氨基酸为丙氨酸、甘氨酸、色氨酸、精氨酸、脯氨酸或丝氨酸。营养组合物含有约 0.1%至 25.0%（按重量计）的低聚肽，最好是约 0.5%至 5.0%（按重量计）。
• Compositions and methods for modulating factor IX function
  申请人：The Children's Hospital of Philadelphia

  公开号：US10676731B2

  公开（公告）日：2020-06-09

  Factor IX/IXa variants and methods of use thereof are disclosed.

  已公开因子 IX/IXa 变体及其使用方法。
• Chimeric clotting factors
  申请人：Bioverativ Therapeutics Inc.

  公开号：US10968442B2

  公开（公告）日：2021-04-06

  Chimeric clotting factors which localize the therapeutic to sites of coagulation (e.g., by being targeted to platelets or being activatable at sites of coagulation), have reduced clearance rates, have improved manufacturability, have reduced thrombogenicity, have enhanced activity, or have more than one of these characteristics are described as are methods for making chimeric clotting factors and methods for improving hemostasis using these clotting factors.

  本文描述了将治疗药物定位在凝血部位（例如，通过靶向血小板或在凝血部位可激活）、降低清除率、改善可制造性、降低血栓形成性、增强活性或具有上述多个特征的嵌合凝血因子，以及制造嵌合凝血因子的方法和使用这些凝血因子改善止血的方法。
• CHIMERIC CLOTTING FACTORS
  申请人：Bioverativ Therapeutics Inc.

  公开号：EP2591099B1

  公开（公告）日：2020-11-18
• COMPOSITIONS AND METHODS FOR MODULATING FACTOR IX FUNCTION
  申请人：The Children's Hospital of Philadelphia

  公开号：EP3490586A2

  公开（公告）日：2019-06-05