N-[(Benzyloxy)carbonyl]phenylalanyltyrosine | 2537-91-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(Benzyloxy)carbonyl]phenylalanyltyrosine
• 英文别名: 3-(4-hydroxyphenyl)-2-[[3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoic acid
• CAS: 2537-91-9
• 化学式: C₂₆H₂₆N₂O₆
• 分子量: 462.5
• InChiKey: PGOQBJBMASKTEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• DIPEPTIDYL ALDEHYDES FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES
  申请人：AXIAVA PHARMA UG

  公开号：US20190030113A1

  公开（公告）日：2019-01-31

  Several parasites responsible for mammalian diseases are dependent on cysteine proteases for various life-cycle functions. Inhibition or decreasing function of specific cysteine proteases can be useful in the treatment and/or prevention of these parasitic diseases including trichomoniasis, histomoniasis, coccidiosis, trypanosomiasis (trypamonosis) and cryptosporidiosis. Compounds of formula I of the invention are capable of treating and/or preventing the above-identified diseases in mammals, e.g. in avian species as Galliformes including chickens, turkeys, ducks, geese, grouse, guinea fowl, peafowl, quail, partridges, and pheasants, Falconiformes, Passiformes, Columbiformes (i.e. Columba livia domestica ), Psittaciformes, and in domestic mammals such as cattle, sheep, goats, horses, pigs, camels, lamas, alpacas, cats and dogs.