2-[[2-[(2-azaniumylacetyl)amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-[(2-azaniumylacetyl)amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoate
• 化学式: C13H17N3O5
• 分子量: 295.29
• InChiKey: INLIXXRWNUKVCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  142
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• SOLOMONAMIDE ANALOGUE COMPOUNDS, PHARMACEUTICALS CONTAINING SOLOMONAMIDE ANALOGUE COMPOUNDS, AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20150291659A1

  公开（公告）日：2015-10-15

  Solomanamide analogues of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogues, including the synthesis of macrocyclic core of Salomanamide analogues. The Solomanamide analogues of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

  公式I的Solomanamide类似物具有抗炎活性，并且具有制备这种类似物的可行合成路线，包括制备Salomanamide类似物的大环核心的合成。公式I的Solomanamide类似物或其药物盐可以在药物组合物中提供，并以有效剂量用于治疗炎症和/或疼痛。
• Amine derivatives of folic acid analogs
  申请人：CYTOGEN CORPORATION

  公开号：EP0251455A2

  公开（公告）日：1988-01-07

  Novel therapeutic antibody conjugates comprising amine derivatives of folic acid analogs covalently attached via a reactive amine group to an oxidized carbohydrate moiety of an antibody or antibody fragment are disclosed. The conjugates retain substantially the same immunorespecificity and immunoreactivity of the unconjugated antibody molecule. The immunospecificity and immunoreactivity of the antibody conjugates permits targeted delivery of the attached therapeutically effective amine derivative of folic acid analogs in vivo. The conjugates are therapeutically effective against a variety of neoplastic and non-neoplastic cellular disorders when administered in vivo. Methods for synthesizing the amine derivatives of folic acid analogs, methods for preparing the antibody conjugates, and methods for use of the conjugates in vivo are also disclosed.

  本研究公开了新型治疗性抗体共轭物，该共轭物由叶酸类似物的胺衍生物组成，通过活性胺基团共价连接到抗体或抗体片段的氧化碳水化合物分子上。共轭物基本上保持了未共轭抗体分子的免疫特异性和免疫活性。抗体共轭物的免疫特异性和免疫活性允许在体内靶向递送叶酸类似物的治疗有效胺衍生物。在体内给药时，这些共轭物对多种肿瘤性和非肿瘤性细胞疾病具有治疗效果。此外，还公开了合成叶酸类似物胺衍生物的方法、制备抗体共轭物的方法以及在体内使用共轭物的方法。
• US5140104A
  申请人：——

  公开号：US5140104A

  公开（公告）日：1992-08-18
• US9751911B2
  申请人：——

  公开号：US9751911B2

  公开（公告）日：2017-09-05
• [EN] ANTIBODY CONJUGATES OF AMINE DERIVATIVES OF FOLIC ACID ANALOGS
  申请人：CYTOGEN CORPORATION

  公开号：WO1987006837A1

  公开（公告）日：1987-11-19

  (EN) Novel therapeutic antibody conjugates comprising amine derivatives of folic acid analogs covalently attached via a reactive amine group to an oxidized carbohydrate moiety of an antibody or antibody fragment. The conjugates retain substantially the same immunospecificity and immunoreactivity of the unconjugated antibody molecule. The immunospecificity and immunoreactivity of the antibody conjugates permits targeted delivery of the attached therapeutically effective amine derivative of folic acid analogs $i(in vivo). The conjugates are therapeutically effective against a variety of neoplastic and non-neoplastic cellular disorders when administered $i(in vivo). Methods for synthesizing the amine derivatives of folic acid analogs, methods for preparing the antibody conjugates, and methods for use of the conjugates $i(in vivo) are also disclosed.(FR) Nouveaux conjugués d'anticorps thérapeutiques comprenant des dérivés d'amine d'analogues de l'acide folique attachés de manière covalente par l'intermédiaire d'un groupe amine réactif à une fraction d'hydrate de carbone oxydé d'un anticorps ou d'un fragment d'anticorps. Les conjugués gardent sensiblement les mêmes immunospécificité et immunoréactivité de la molécule d'anticorps non conjuguée. L'immunospécificité et l'immunoréactivité des conjugués d'anticorps permettent l'apport ciblé du dérivé d'amine attaché, thérapeutiquement efficace des analogues de l'acide folique $i(in vivo). Les conjugués sont thérapeutiquement efficaces contre une variété de troubles cellulaires néoplastiques et non néoplastiques lorsqu'ils sont administrés $i(in vivo). Des procédés de synthèse des dérivés d'amine des analogues de l'acide folique, des procédés de préparation des conjugués d'anticorps, et des procédés d'utilisation des conjugués $i(in vivo) sont également décrits.