2-[[4-[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid | 80360-10-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[4-[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• CAS: 80360-10-7
• 化学式: C₂₁H₂₃N₇O₅
• 分子量: 453.5
• InChiKey: DSXZZNYIRMPBTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  198
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  (2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methanol;undecahydrochloride 生成 2-[[4-[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
  参考文献：
  名称：

  TEMPLE, C. G.;MONTGOMERY, A.;ELLIOTT, R. D.

  摘要：

  DOI：

文献信息

• 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
  申请人：Southern Research Institute

  公开号：US04526964A1

  公开（公告）日：1985-07-02

  There is disclosed a novel intermediate useful in the preparation of pyrido [2,3-d] pyrimidines, which includes N-[4-[(2-amino-4(3H)-oxopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L -glutamic acid (5-deazafolic acid), N-[4-[[2-amino-4(3H)-oxopyrido[2,3-d]-pyrimidin-6-yl)methyl]methylamino]be nzoyl]-L-glutamic acid (5-deaza-N.sup.10 -methylfolic acid), N-(4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-gluta mic acid (5-deazaaminopterin), and N-[4-[[2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]methylamino]benzoyl]- L-glutamic acid (5-deazamethotrexate). This intermediate is the compound 2,4-diamino-6-(hydroxymethyl)pyrido-[2,3-d]pyrimidine.

  本发明揭示了一种在制备吡啶并[2,3-d]嘧啶类化合物中有用的新型中间体，包括N-[4-[(2-氨基-4(3H)-氧代吡啶[2,3-d]嘧啶-6-基)甲基氨基]苯甲酰基]-L-谷氨酸(5-去氧叶酸)、N-[4-[[2-氨基-4(3H)-氧代吡啶[2,3-d]嘧啶-6-基)甲基]甲基氨基]苯甲酰基]-L-谷氨酸(5-去氧-N.sup.10-甲基叶酸)、N-(4-[(2,4-二氨基吡啶[2,3-d]嘧啶-6-基)甲基氨基]苯甲酰基)-L-谷氨酸(5-去氧氨基喹噁啉)和N-[4-[[2,4-二氨基吡啶[2,3-d]嘧啶-6-基)甲基]甲基氨基]苯甲酰基]-L-谷氨酸(5-去氧甲氧苯磺酸甲氨蝶呤)。该中间体是化合物2,4-二氨基-6-(羟甲基)吡啶[2,3-d]嘧啶。
• Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
  申请人：Southern Research Institute

  公开号：US10953017B2

  公开（公告）日：2021-03-23

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.

  本文描述了通过服用某些杂环化合物和芳香族化合物来增强记忆和/或学习能力并防止神经变性的方法。这些方法特别适用于治疗神经退行性疾病患者，如（但不限于）阿尔茨海默氏症、帕金森氏症、卢盖里氏症（ALS）或记忆或学习障碍。此外，还提供了一种基于神经元人体细胞的检测方法，利用荧光素酶报告物评估 NF-kB 基因的上调，从而筛选出在增强记忆或学习能力的方法中有用的化合物。
• TEMPLE, C. G.;MONTGOMERY, J. A.;ELLIOTT, R. D.
  作者：TEMPLE, C. G.、MONTGOMERY, J. A.、ELLIOTT, R. D.

  DOI：——

  日期：——
• TEMPLE, C. G.;MONTGOMERY, A.;ELLIOTT, R. D.
  作者：TEMPLE, C. G.、MONTGOMERY, A.、ELLIOTT, R. D.

  DOI：——

  日期：——
• THERAPEUTIC POLYESTERS AND POLYAMIDES
  申请人：Uhrich Kathryn E.

  公开号：US20080233078A1

  公开（公告）日：2008-09-25

  Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.