L-丙氨酰-N-[(1S)-3-氯-2-氧代-1-(苯基甲基)丙基]-L-丙氨酰胺 | 102129-66-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-丙氨酰-N-[(1S)-3-氯-2-氧代-1-(苯基甲基)丙基]-L-丙氨酰胺
• 英文名称: (2S)-2-amino-N-[(2S)-1-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-1-oxopropan-2-yl]propanamide
• CAS: 102129-66-8
• 化学式: C₁₆H₂₂ClN₃O₃
• 分子量: 339.82
• InChiKey: ONICONPPGVXITG-GVXVVHGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] HIGH-THROUGHPUT SCREENING OF REGULATORS OF AXONAL TRANSPORT<br/>[FR] CRIBLAGE À HAUT DÉBIT DE RÉGULATEURS DU TRANSPORT AXONAL
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2020149925A1

  公开（公告）日：2020-07-23

  Provided herein are techniques for processing a sequence of images of neurons to identify stationary and motile organelles of the neurons, generating tracking data associated with movement of the one or more motile organelles across the sequence of images, and determining an overall percent motile based on the identified stationary organelles and motile organelles. Also provided herein are compounds identified using the systems described herein, wherein the compounds, and pharmaceutically acceptable salts, and compositions thereof are administered to a subject in need thereof in a sufficient amount to increase or promote organelle (e.g., mitochondrial) motility, or administered in a sufficient amount to treat a disease or disorder associated with decreased organelle motility. The compounds described herein may be used in methods for increasing or promoting organelle (e.g., mitochondrial) motility in a cell, and methods for treating a disease. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.