7-methyl-3-phenyl-2,7-naphthyridin-1(7H)-one | 109409-75-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7-methyl-3-phenyl-2,7-naphthyridin-1(7H)-one
• 英文别名: 2-methyl-8-oxo-6-phenyl-7,8-dihydro-[2,7]naphthyridinium-betaine；2-Methyl-8-oxo-6-phenyl-7,8-dihydro-[2,7]naphthyridinium-betain；7-Methyl-3-phenyl-2,7-naphthyridin-1-one
• CAS: 109409-75-8
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: FLVFCFDIYORZPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Nicotinic-acid-1-methyldiamidebromide 在 氢溴酸 、 N,N-二甲基-4-亚硝基苯胺 作用下， 生成 7-methyl-3-phenyl-2,7-naphthyridin-1(7H)-one
  参考文献：
  名称：

  Kroehnke et al., Justus Liebigs Annalen der Chemie, 1956, vol. 600, p. 176,188

  摘要：

  DOI：

文献信息

• THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  申请人：PELLICCIARI Roberto

  公开号：US20090318442A1

  公开（公告）日：2009-12-24

  The present invention relates to substituted thiazolyl- and oxazoyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代噻唑基和噁唑基异喹啉酮，例如作为多聚腺苷二磷酸核糖聚合酶（PARP）的调节剂。本发明还涉及替代噻唑基和噁唑基异喹啉酮的制备方法以及它们在治疗各种疾病和紊乱中的应用。
• An improved fluorogenic NAD(P)+ detection method using 2-acetylbenzofuran: its origin and application
  作者：Takashi Moriya、Ayano Kawamata、Yusuke Takahashi、Yoshiharu Iwabuchi、Naoki Kanoh

  DOI：10.1039/c3cc47264g

  日期：——

  We have developed a fluorogenic NAD(P)+ detection method using 2-acetylbenzofuran. The reaction of NAD(P)+ with 2-acetylbenzofuran produced a fluorescent product, allowing the highly-sensitive and quick detection of NAD(P)+. This method was successfully applied to the detection of P450 substrates in the microtiter-plate format.

  我们利用 2-acetylbenzofuran 开发了一种荧光 NAD(P)+ 检测方法。NAD(P)+ 与 2-acetylbenzofuran 反应产生荧光产物，从而实现了对 NAD(P)+ 的高灵敏度和快速检测。该方法被成功应用于微孔板形式的 P450 底物检测。
• THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM
  申请人：Pellicciari Roberto

  公开号：US20090325951A1

  公开（公告）日：2009-12-31

  The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代噻吩基和呋吩基异喹啉酮，例如作为聚(ADP-核糖)聚合酶(PARP)调节剂。本发明还涉及制备替代噻吩基和呋吩基异喹啉酮的过程，以及它们在治疗各种疾病和疾病方面的用途。
• Thiazolyl- and Oxazolyl-Isoquinolinones and Methods for Using Them
  申请人：Pellicciari Roberto

  公开号：US20130059843A1

  公开（公告）日：2013-03-07

  The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及替代噻唑基和氧唑基异喹啉酮，例如作为多聚(ADP核糖)聚合酶（PARP）调节剂。本发明还涉及制备替代噻唑基和氧唑基异喹啉酮的方法，以及它们在治疗各种疾病和障碍中的应用。
• Thiazolyl- And Oxazolyl-Isoquinolinones And Methods For Using Them
  申请人：Pellicciari Roberto

  公开号：US20150133443A1

  公开（公告）日：2015-05-14

  The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

  本发明涉及取代噻唑基和噁唑基异喹啉酮，例如作为聚(ADP-核糖)聚合酶(PARP)调节剂的化合物。本发明还涉及制备取代噻唑基和噁唑基异喹啉酮的方法，以及它们在治疗各种疾病和疾病中的应用。