L-甘油-L-半乳-七糖醇,2,6-脱水-,1,4,7-三(4-甲基苯磺酸酯) | 83270-36-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: L-甘油-L-半乳-七糖醇,2,6-脱水-,1,4,7-三(4-甲基苯磺酸酯)
• 英文名称: Bis(2-hydroxypropyl)ammonium myristate
• 英文别名: 1-(2-hydroxypropylamino)propan-2-ol;tetradecanoic acid
• CAS: 83270-36-4
• 化学式: C14H28O2.C6H15NO2
• 分子量: 361.6
• InChiKey: WPHZDLROOHEOOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  25
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  97.2
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Composition for Patch Preparation Comprising Drug, Organic Solvent, Lipophilic Mass Base, and Powder
  申请人：MEDRX CO., LTD.

  公开号：US20150174249A1

  公开（公告）日：2015-06-25

  The present disclosure provides a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug.

  本公开提供了一种具有良好粘附性和可持续释放药物的非水性贴剂制剂组合物。通过添加粉末成分，该贴剂制剂可以改善贴剂制剂的粘附性和药物的释放性能，贴剂制剂的长时间粘附性能有助于提高经皮吸收性和药物的持续释放。
• ADHESIVE PREPARATION COMPOSITION OBTAINED BY BLENDING DRUG, ORGANIC SOLVENT, LIPOPHILIC OINTMENT BASE, AND POWDER
  申请人：Medrx Co., Ltd.

  公开号：EP2865376A1

  公开（公告）日：2015-04-29

  The object of the present invention is to provide a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation of the present invention can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient (a filler or the like). As a result, the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug. By the use of a composition for a patch preparation comprising this powder ingredient, a drug, regardless of the type of a drug is dissolved in an organic solvent or an ionic liquid to prepare a drug solution comprising the organic solvent, the drug solution is incorporated into the non-aqueous parch preparation of the present invention, and thereby a preparation with the improved transdermal absorbability and the improved sustained release can prepared.

  本发明的目的是提供一种可持续释放药物的非水贴剂组合物，该组合物具有极佳的粘附性。本发明的贴片制剂可以通过添加粉末成分（填料或类似物）来改善贴片制剂的粘附性和药物释放性能。因此，长期保持贴片制剂的粘附性可以提高药物的透皮吸收性和持续释放性。通过使用包含这种粉末成分的贴片制剂组合物，将药物（无论药物类型）溶解在有机溶剂或离子液体中，制备出包含有机溶剂的药物溶液，然后将药物溶液加入到本发明的非水基贴片制剂中，从而制备出具有改善的透皮吸收性和改善的持续释放性的制剂。
• NOVEL BASE COMPOSITION FOR TAPE AGENT
  申请人：MEDRx Co., Ltd.

  公开号：EP3045166A1

  公开（公告）日：2016-07-20

  The object of the present invention is to provide a composition for a non-aqueous patch preparation having an excellent adhesibility which can sustainedly release a drug. The patch preparation of the present invention can improve the adhesibility thereof as well as the release property of a drug by the addition of powder ingredient (e.g. a filler). As a result, the long-time sustention of the adhesibility of patch preparations can achieve the improvement of the transdermal absorbability and the sustained release of a drug. By the use of a composition for a patch preparation comprising this powder ingredient, a drug, regardless of the type of a drug is dissolved in an organic solvent or an ionic liquid to prepare a drug solution comprising the organic solvent, the drug solution is incorporated into the non-aqueous patch preparation of the present invention, and thereby a preparation with the improved transdermal-absorbability and sustained release can prepared.

  本发明的目的是提供一种用于非水贴剂制备的组合物，该组合物具有极佳的粘附性，可持续释放药物。 本发明的贴剂制剂可以通过添加粉末成分（如填充剂）来提高其粘附性以及药物释放性能。因此，长期保持贴片制剂的粘附性可以提高药物的透皮吸收性和持续释放性。通过使用包含这种粉末成分的贴剂制剂组合物，将药物（无论药物类型）溶解在有机溶剂或离子液体中，制备出包含有机溶剂的药物溶液，将药物溶液加入到本发明的非水贴剂制剂中，从而制备出具有改善的透皮吸收性和持续释放性的制剂。
• PRAMIPEXOLE-CONTAINING TRANSDERMAL PATCH FOR TREATMENT OF NEURODEGENERATIVE DISEASE
  申请人：Medrx Co., Ltd.

  公开号：EP3111935A1

  公开（公告）日：2017-01-04

  [Problem] Provided is a stable nonaqueous tape preparation demonstrating superior percutaneous absorption that contains highly crystalline pramipexole hydrochloride that is poorly soluble in organic solvent. [Solution to Problem] The present invention enabled the production of a stable tape preparation that demonstrates superior percutaneous absorption by using the combination of a fatty acid-based ionic liquid, divalent alcohol and fatty acid ester and dissolving pramipexole therein. As a result, a tape preparation containing pramipexole hydrochloride can be provided for the treatment of Parkinson's disease.

  问题 本发明提供了一种稳定的非水基胶带制剂，它含有在有机溶剂中溶解度低的高结晶盐酸普拉克索，具有良好的经皮吸收性。 [问题解决方案］ 本发明通过使用脂肪酸基离子液体、二价醇和脂肪酸酯的组合，并将普拉克索溶解在其中，从而生产出一种稳定的胶带制剂，这种胶带制剂具有优异的经皮吸收性。因此，本发明可提供一种含有盐酸普拉克索的胶带制剂，用于治疗帕金森病。
• NOVEL COMPOSITION FOR PLASTER BASE MATERIAL IN TAPE PREPARATION
  申请人：MEDRx Co., Ltd.

  公开号：EP3824883A1

  公开（公告）日：2021-05-26

  The present invention relates to a composition for a non-aqueous patch preparation comprising a drug, an organic solvent, and a powder which is insoluble both in the organic solvent and in a lipophilic plaster base material, wherein the organic solvent comprises a fatty acid-based ionic liquid and/or a salicylic acid-based ionic liquid, the powder is light anhydrous silicic acid, and the powder for an adhesive layer is contained as shown in the following inequality: 0.2×the weight of the adhesive layer×the bulk density of the powder≤the amount of the powder to be added≤0.6×the weight of the adhesive layer×the tap density of the powder.

  本发明涉及一种用于非水贴剂制备的组合物，该组合物由药物、有机溶剂和既不溶于有机溶剂又不溶于亲脂性石膏基质材料的粉末组成，其中有机溶剂包括脂肪酸基离子液体和/或水杨酸基离子液体，粉末为轻质无水硅酸，用于粘合层的粉末的含有量如下不等式所示：0.2×粘合剂层的重量×粉末的体积密度≤粉末的添加量≤0.6×粘合剂层的重量×粉末的自重密度。