1-hydroxy-2-[(E)-(2,4,5-trimethoxyphenyl)methylideneamino]guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-hydroxy-2-[(E)-(2,4,5-trimethoxyphenyl)methylideneamino]guanidine
• 化学式: C₁₁H₁₆N₄O₄
• 分子量: 268.27
• InChiKey: AXLNFFUCIUXDJD-AWNIVKPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• METHOD OF TREATING INFLAMMATION
  申请人：AnaMar AB

  公开号：US20130295009A1

  公开（公告）日：2013-11-07

  The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R 1 , R 2 , R 3 , R 4 and R 5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof;
• US8309609B2
  申请人：——

  公开号：US8309609B2

  公开（公告）日：2012-11-13
• US8410174B2
  申请人：——

  公开号：US8410174B2

  公开（公告）日：2013-04-02