sulfanilic acid ; hydrochloride | 63317-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sulfanilic acid ; hydrochloride
• 英文别名: Sulfanilsaeure; Hydrochlorid；4-Aminobenzenesulfonic acid;hydrochloride；4-aminobenzenesulfonic acid;hydrochloride
• CAS: 63317-90-8
• 化学式: C₆H₇NO₃S*ClH
• 分子量: 209.653
• InChiKey: QLKPEODFPFEGSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.94
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  sulfanilic acid ; hydrochloride 在 氯化亚砜 作用下， 以 乙醇 为溶剂， 生成 N¹-<4-Sulfonyl-phenyl>-N⁵,N⁵-bis-<2-chlor-aethyl>-biguanid
  参考文献：
  名称：

  Sen,A.B.; Chatterjee,S.S., Journal of the Indian Chemical Society, 1965, vol. 42, p. 547 - 551

  摘要：

  DOI：
• 作为产物：
  描述：

  sodium sulfanilate 在 盐酸 、 水 作用下， 生成 sulfanilic acid ; hydrochloride
  参考文献：
  名称：

  Witt, Chemische Berichte, 1888, vol. 21, p. 3481

  摘要：

  DOI：

文献信息

• Synthesis and spectral properties of symmetrical and asymmetrical 3-cyano-1,5-diarylformazan dyestuffs for dyeing polyester fabrics
  作者：Tawfik Khattab、Karima M. Haggag

  DOI：10.21608/ejchem.2017.1479.1103

  日期：2017.12.1

  In this study, we report on a general synthetic approach to both symmetrical and asymmetrical 3-cyano-1,5-diarylformazan dyes. The reaction of enaminonitrile with aromatic diazonium salts in slightly acidic medium affords arylhydrazonals as stable intermediate that are readily converted into asymmetrical formazans via second azo-coupling in a weak alkaline medium. Symmetrical formazan dyestuffs are synthesized directly via double azo-coupling of the key intermediate 3-piperidinylacrylonitrile with the corresponding diazonium salts in weak alkaline medium using sodium acetate as a weak base. The structures of the prepared dyestuffs and intermediates are demonstrated by elemental analysis (C, H, N), 1H and 13C NMR, FTIR and GC-MS spectroscopic techniques. The prepared formazan disperse colorants are applied to dye polyester fabric to give satisfactory fastness properties to wash, perspiration, rubbing and light.

  在本研究中，我们报告了一种合成对称和非对称3-氰基-1,5-二芳基福尔马赞染料的普遍合成方法。酰胺氰与芳香族重氮盐在稍微酸性的介质中反应，生成作为稳定中间体的芳基肼醛，这些中间体可以通过在弱碱介质中进行二次偶氮偶联反应，转化为非对称福尔马赞。对称福尔马赞染料则通过将关键中间体3-哌啶基丙烯腈与相应的重氮盐在弱碱性介质中进行双偶氮偶联反应直接合成，采用醋酸钠作为弱碱。通过元素分析（C、H、N）、1H和13C NMR、FTIR和GC-MS光谱技术证明所制备染料和中间体的结构。所制备的福尔马赞分散色料应用于聚酯面料的染色，获得良好的洗涤、汗液、摩擦和光照的牢度性能。
• Novel 2,3-disubstituted primary para-phenylenediamines and process for oxidation dyeing of keratin fibers
  申请人：Ramos-Stanbury Laure

  公开号：US20070011823A1

  公开（公告）日：2007-01-18

  Disclosed herein are para-phenylenediamine compounds of formula (I), and their salts and solvates: wherein R 1 and R 2 form, together with the carbon atoms to which they are attached, a 4-, 5-, 6- or 7-membered ring, wherein the ring comprises carbon atoms and, optionally, one or two atoms chosen from oxygen and nitrogen, the ring being optionally substituted, with the proviso that when the ring comprises two atoms chosen from oxygen and nitrogen, these two atoms are non-adjacent. Compositions comprising these compounds and processes of making them, as well as processes and kits for dyeing keratin fibers are also disclosed.

  本文披露了化学式(I)的对苯二胺化合物及其盐和溶剂合物：其中R1和R2与它们附着的碳原子一起形成4、5、6或7成员环，该环包括碳原子，可选择地包括一个或两个来自氧和氮的原子，该环可选择地被取代，但当环包括两个来自氧和氮的原子时，这两个原子不相邻。还披露了包含这些化合物的组合物、制备它们的方法，以及用于染色角蛋白纤维的方法和工具箱。
• METHOD OF PRODUCING A SODIUM SALT OF (2,6-DICHLOROPHENYL)AMIDE CARBOPENTOXYSULFANILIC ACID
  申请人：TETS Viktor Veniaminovich

  公开号：US20180244612A1

  公开（公告）日：2018-08-30

  The invention relates to the field of organic chemistry and medicine, and more particularly to a method of producing synthetic biologically active derivatives of carbopentoxysulfanilic acid. The present method of producing a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid is characterized in that the reaction mass formed during the production of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid is agitated in a medium which is acidified with a solution of hydrochloric acid to pH 5-5.5, and the isolated precipitate may be washed with water acidified with a solution of hydrochloric acid to pH 5-5.5. This increases the yield of a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid to 70% (compared to a prior art yield of 32%) and also increases the purity of the target sodium salt.

  本发明涉及有机化学和医药领域，更具体地涉及一种生产合成生物活性的卡波戊酰氨基苯磺酸衍生物的方法。制备(2,6-二氯苯基)酰胺卡波戊酰氨基苯磺酸的反应物混合物在中和成pH值为5-5.5的盐酸溶液的介质中搅拌，所得的沉淀物可以用pH值为5-5.5的盐酸溶液酸化的水洗涤。这将使得(2,6-二氯苯基)酰胺卡波戊酰氨基苯磺酸的钠盐产量提高至70％（相比之前的产量为32％），并且提高了目标钠盐的纯度。
• METHOD OF PRODUCING A SODIUM SALT OF (2,6-DICHLOROPHENYL)AMIDE CARBOPENTOXYSULPHANILIC ACID
  申请人：Tets, Viktor Veniaminovich

  公开号：EP3351530A1

  公开（公告）日：2018-07-25

  The invention relates to the field of organic chemistry and medicine, and more particularly to a method of producing synthetic biologically active derivatives of carbopentoxysulfanilic acid. The present method of producing a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid, which includes synthesizing (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid by mixing 2,6-dichloroaniline and pyridine, then adding carbopentoxysulfanilic acid chloride to the mixture, agitating the reaction mass in a medium acidified by a solution of hydrochloric acid, isolating the precipitate and washing and drying same, and also includes subsequently synthesizing a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid by mixing ethanol solutions of caustic soda and (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid, agitating the resultant mixture, distilling off the ethanol and drying the precipitate, is characterized in that the reaction mass formed during the production of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid is agitated in a medium which is acidified with a solution of hydrochloric acid to pH 5-5.5, and the isolated precipitate may be washed with water acidified with a solution of hydrochloric acid to pH 5-5.5. This increases the yield of a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid to 70% (compared to a prior art yield of 32%) and also increases the purity of the target sodium salt.

  本发明涉及有机化学和医药领域，更具体地说，涉及一种生产碳戊氧羰基苯磺酸的合成生物活性衍生物的方法。本发明生产(2,6-二氯苯基)酰胺碳戊氧羰基苯磺酸钠盐的方法，包括将 2,6-二氯苯胺和吡啶混合合成(2,6-二氯苯基)酰胺碳戊氧羰基苯磺酸、将 2,6-二氯苯胺和吡啶混合，合成(2,6-二氯苯基)酰胺碳五氧基苯磺酸，然后向混合物中加入碳五氧基苯磺酰氯，在盐酸溶液酸化的介质中搅拌反应物，分离沉淀并洗涤和干燥，还包括随后合成(2,6-二氯苯基)酰胺的钠盐、6-dichlorophenyl)amide carbopentoxysulfanilic acid 的钠盐，方法是混合苛性钠和 (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid 的乙醇溶液，搅拌所得混合物，蒸馏掉乙醇并干燥沉淀、其特征在于在生产 (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid 过程中形成的反应物在用盐酸溶液酸化至 pH 5-5.5，分离出的沉淀可用盐酸溶液酸化至 pH 5-5.5 的水洗涤。这样，(2,6-二氯苯基)酰胺碳戊氧羰基苯磺酸钠盐的产率提高到 70%（而现有技术的产率为 32%），同时也提高了目标钠盐的纯度。
• Method of producing a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid
  申请人：Tets Viktor Veniaminovich

  公开号：US10584095B2

  公开（公告）日：2020-03-10

  The invention relates to the field of organic chemistry and medicine, and more particularly to a method of producing synthetic biologically active derivatives of carbopentoxysulfanilic acid. The present method of producing a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid is characterized in that the reaction mass formed during the production of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid is agitated in a medium which is acidified with a solution of hydrochloric acid to pH 5-5.5, and the isolated precipitate may be washed with water acidified with a solution of hydrochloric acid to pH 5-5.5. This increases the yield of a sodium salt of (2,6-dichlorophenyl)amide carbopentoxysulfanilic acid to 70% (compared to a prior art yield of 32%) and also increases the purity of the target sodium salt.

  本发明涉及有机化学和医药领域，更具体地说，涉及一种生产碳戊氧羰基苯磺酸的合成生物活性衍生物的方法。本发明生产(2,6-二氯苯基)酰胺碳戊氧羰基苯磺酸钠盐的方法，其特征在于将生产(2,6-二氯苯基)酰胺碳戊氧羰基苯磺酸过程中形成的反应物在用盐酸溶液酸化至pH5-5.5的介质中搅拌，分离出的沉淀可用盐酸溶液酸化至pH5-5.5的水洗涤。这样，(2,6-二氯苯基)酰胺碳戊氧羰基苯磺酸钠盐的产率提高到 70%（而现有技术的产率为 32%），同时也提高了目标钠盐的纯度。