L-精氨酸-α-酮异己酸盐 | 72087-40-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-精氨酸-α-酮异己酸盐
• 中文别名: L-精氨酸-Α-酮异己酸盐(1:1)KIC
• 英文名称: arginine alpha-ketoisocaproate
• 英文别名: arginine α-ketoisocaproate；arginine ketoisocaproate；[(4S)-4-amino-4-carboxybutyl]-(diaminomethylidene)azanium;4-methyl-2-oxopentanoate
• CAS: 72087-40-2
• 化学式: C₆H₁₀O₃*C₆H₁₄N₄O₂
• 分子量: 304.346
• InChiKey: MOZIGXHKOXEDLJ-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.65
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  182
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• PERFORMANCE ENHANCING COMPOSITION
  申请人：HeartBeet Ltd.

  公开号：EP3159000A1

  公开（公告）日：2017-04-26

  The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.

  通过向哺乳动物施用无毒量的硝酸盐和/或亚硝酸盐，可以提高哺乳动物的运动表现，表现为运动期间摄氧量（VO2）的降低。可提供液体、半固体和固体零食和食品以及营养补充剂，如运动饮料。
• Performance enhancing composition and use thereof
  申请人：HeartBeet Ltd.

  公开号：US10555968B2

  公开（公告）日：2020-02-11

  The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.

  通过向哺乳动物施用无毒量的硝酸盐和/或亚硝酸盐，可以提高哺乳动物的运动表现，表现为运动期间摄氧量（VO2）的降低。可提供液体、半固体和固体零食和食品以及营养补充剂，如运动饮料。
• Compositions of nitrates and methods of use thereof
  申请人：Heartbeet Ltd.

  公开号：US10821132B2

  公开（公告）日：2020-11-03

  Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a reduction in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.

  无机阴离子硝酸盐和亚硝酸盐会影响新陈代谢率和葡萄糖稳态。输注亚硝酸盐 iv 会导致静息能量消耗（耗氧量）急剧下降，而口服硝酸盐会导致运动时耗氧量减少，并抑制口服葡萄糖耐量试验后观察到的血糖升高。硝酸盐和亚硝酸盐的剂量不会导致血液中高铁血红蛋白水平发生任何可检测到的变化。此外，硝酸盐和亚硝酸盐也不会改变血液中的乳酸水平。这一发现为通过服用无机亚硝酸盐和/或硝酸盐来调节哺乳动物的能量消耗和葡萄糖平衡提供了有用的治疗方法。
• EP1996199A4
  申请人：——

  公开号：EP1996199A4

  公开（公告）日：2009-07-15
• COMPOSITIONS FOR PREVENTING AND REDUCING DELAYED ONSET MUSCLE SORENESS
  申请人：Southwest Immunology Inc.

  公开号：EP1973426A2

  公开（公告）日：2008-10-01