1-bromo-3-(p-methoxyphenyl)bicyclo<1.1.1>pentane | 156329-65-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-bromo-3-(p-methoxyphenyl)bicyclo<1.1.1>pentane
• 英文别名: 1-Bromo-3-(4-methoxyphenyl)bicyclo[1.1.1]pentane
• CAS: 156329-65-6
• 化学式: C₁₂H₁₃BrO
• 分子量: 253.139
• InChiKey: BEYPPUBHZULNMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (2-Sulfanylidenepyridin-1-yl) 3-(4-methoxyphenyl)bicyclo[1.1.1]pentane-1-carboxylate 在 氟烷 作用下， 以81%的产率得到1-bromo-3-(p-methoxyphenyl)bicyclo<1.1.1>pentane
  参考文献：
  名称：

  Synthesis of Some Bridgehead-Bridgehead-Disubstituted Bicyclo[1.1.1]pentanes

  摘要：

  The synthesis of a wide variety of 1,3-disubstituted bicyclo[1.1.1]pentanes is described, with particular emphasis on the generation of a series of S-X-substituted bicyclo[1.1.1]pentyl bromides required for solvolytic studies. Functional group manipulation at the bridgehead was readily accomplished in the majority of cases by radical processes in some instances, transformations were effected via carbanionic-type intermediates.

  DOI：

  10.1021/jo00090a015

文献信息

• Synthesis of Some Bridgehead-Bridgehead-Disubstituted Bicyclo[1.1.1]pentanes
  作者：Ernest W. Della、Dennis K. Taylor

  DOI：10.1021/jo00090a015

  日期：1994.6

  The synthesis of a wide variety of 1,3-disubstituted bicyclo[1.1.1]pentanes is described, with particular emphasis on the generation of a series of S-X-substituted bicyclo[1.1.1]pentyl bromides required for solvolytic studies. Functional group manipulation at the bridgehead was readily accomplished in the majority of cases by radical processes in some instances, transformations were effected via carbanionic-type intermediates.