1,2-dimethyl-3,4-bis-(methylcarbamoyloxy-methyl)-5-phenyl-pyrrole | 70303-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,2-dimethyl-3,4-bis-(methylcarbamoyloxy-methyl)-5-phenyl-pyrrole
• 英文别名: [1,2-dimethyl-4-(methylcarbamoyloxymethyl)-5-phenylpyrrol-3-yl]methyl N-methylcarbamate
• CAS: 70303-71-8
• 化学式: C₁₈H₂₃N₃O₄
• 分子量: 345.398
• InChiKey: ZJEXQDNDIBIJCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL DNA-TARGETED ALKYLATING AGENTS
  申请人：AUCKLAND DIVISION CANCER SOCIETY OF NEW ZEALAND (INCORPORATED)

  公开号：EP0777656A1

  公开（公告）日：1997-06-11
• EP0777656A4
  申请人：——

  公开号：EP0777656A4

  公开（公告）日：1998-04-15
• METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO (6,7-B) INDOLE DERIVATIVES
  申请人：Academia Sinica

  公开号：EP3515437A1

  公开（公告）日：2019-07-31
• METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO[6,7-B]INDOLE DERIVATIVES
  申请人：SU Tsann-Long

  公开号：US20190247371A1

  公开（公告）日：2019-08-15

  A method for treating small cell lung cancer (SCLC). In the method, a therapeutically effective amount of a compound of Formula I: wherein R 1 , R 2 and R 3 have the definitions disclosed in the specification is administered alone or in combination with one or more anticancer agents, or surgery, radiation therapy, chemotherapy, and/or targeted therapy.
• US4734423A
  申请人：——

  公开号：US4734423A

  公开（公告）日：1988-03-29