3-(hydroxyamino)-6-methoxyindol-2-one | 1067232-92-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(hydroxyamino)-6-methoxyindol-2-one
• CAS: 1067232-92-1
• 化学式: C₉H₈N₂O₃
• 分子量: 192.174
• InChiKey: XGDOGERKBQXBJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.83
• 重原子数：
  14.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  70.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-(hydroxyimino)-N-(3-methoxyphenyl)acetamide 在 tetrafluoroboric acid 、 1-丁基-3-甲基咪唑二(三氟甲基磺酰)酰亚胺 作用下， 反应 1.5h， 以81%的产率得到3-(hydroxyamino)-6-methoxyindol-2-one
  参考文献：
  名称：

  Pronounced ionic liquid effect in the synthesis of biologically active isatin-3-oxime derivatives under acid catalysis

  摘要：

  An efficient method was developed for the preparation of isatin-3-oxime derivatives with Bronsted and/ or Lewis acids in irniclazoliurn-based ionic liquids. Isatin-3-oxime bearing the electron donating methoxy group was equally obtained in good yields.The pronounced ionic liquid effect avoids the direct forniation of isatin in the acidified media and the reaction leads exclusively to isatin-3-oxime derivatives. 0 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.067

文献信息

• Pronounced ionic liquid effect in the synthesis of biologically active isatin-3-oxime derivatives under acid catalysis
  作者：Angelo C. Pinto、Alexandre A. Moreira Lapis、Barbara Vasconcellos da Silva、Renato S. Bastos、Jaïrton Dupont、Brenno A.D. Neto

  DOI：10.1016/j.tetlet.2008.07.067

  日期：2008.9

  An efficient method was developed for the preparation of isatin-3-oxime derivatives with Bronsted and/ or Lewis acids in irniclazoliurn-based ionic liquids. Isatin-3-oxime bearing the electron donating methoxy group was equally obtained in good yields.The pronounced ionic liquid effect avoids the direct forniation of isatin in the acidified media and the reaction leads exclusively to isatin-3-oxime derivatives. 0 2008 Elsevier Ltd. All rights reserved.