L-谷氨酸与L-谷氨酸5-乙基酯聚合物 | 29323-51-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-谷氨酸与L-谷氨酸5-乙基酯聚合物
• 英文名称: (2S)-2-amino-5-ethoxy-5-oxopentanoic acid;(2S)-2-aminopentanedioic acid
• CAS: 29323-51-1
• 化学式: C12H22N2O8
• 分子量: 322.31
• InChiKey: ASXAKDGYAFEILU-RVZXSAGBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.0
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  190
• 氢给体数：
  5
• 氢受体数：
  10

安全信息

• WGK Germany：
  3

文献信息

• Colloidal suspension of submicronic particles for delivering active principles and method for preparing same
  申请人：Caillol Sylvain

  公开号：US20070190162A1

  公开（公告）日：2007-08-16

  The present invention is directed to a suspension of particles for delivering active principles, in particular proteins. Said particles are based on a diblock copolymer consisting of a neutral hydrophobic alpha hydroxy carboxylic acid polymer block and a hydrophilic linear polyaminoacid block with peptide alpha chaining, at least partly ionized. Said alpha hydroxy carboxylic acid polymer/linear polyaminoacid delivery particles spontaneously obtainable in the absence of surfactant can be stable. Said delivery particles are capable of being associated undissolved in colloidal suspension with at least an active principle and of delayed or prolonged release thereof. The invention is also directed to a powdery solid from which are derived the delivery particles and the preparation of said solid and said delivery particle suspension.

  本发明涉及一种颗粒悬浮液，用于传递活性成分，特别是蛋白质。所述颗粒基于二嵌段共聚物，包括一个中性疏水α羟基羧酸聚合物块和一个亲水线性多肽酸块，具有肽α链，至少部分离子化。所述α羟基羧酸聚合物/线性多肽酸传递颗粒在无表面活性剂的情况下可以稳定地获得。所述传递颗粒能够与至少一种活性成分以胶体悬浮的形式结合，延迟或延长其释放。本发明还涉及一种粉末固体，用于制备传递颗粒和该固体及传递颗粒悬浮液的制备。
• Colloidal suspension of submicronic particles as vectors for active principles and method for preparing same
  申请人：Touraud Franck

  公开号：US20070248686A1

  公开（公告）日：2007-10-25

  A suspension of vector particles (PV) based on polyamino acids and have a mean hydrodynamic diameter between 30 and 120 nm, and an insulin load factor of from 5 to 25% of associated insulin volume relative to the polyamino acid volume forming the vector particles. The polyamino acids are double-block polymers containing hydrophilic and hydrophobic monomers. The suspension may be prepared by copolymerizing N-carboxy anhydrides of hydrophobic monomers and precursors of hydrophilic monomers, in the presence of N-methyl pyrrolidone and methanol. The copolymer is optionally neutralized, subjected to dialysis, concentrated and water is eliminated to produce a solid powder, which can be suspended in a liquid to produce the colloidal suspension. Active principles such as insulin or vaccines are associated with the carrier particles to prepare special pharmaceutical products.

  一种基于多聚氨基酸的载体粒子（PV）悬浮液，其平均流体动力学直径在30至120纳米之间，胰岛素负载因子相对于形成载体粒子的多聚氨基酸体积而言为5至25％。多聚氨基酸是含有亲水性和疏水性单体的双嵌段聚合物。该悬浮液可以通过在N-甲基吡咯烷酮和甲醇的存在下共聚合疏水性单体的N-羧酸酐和亲水性单体的前体来制备。共聚物可以选择性中和，经过透析、浓缩和去除水分以产生固体粉末，该粉末可以悬浮在液体中以产生胶体悬浮液。将胰岛素或疫苗等活性成分与载体粒子关联以制备特殊的制药产品。
• System and method for delivering a therapeutic agent over an extended period of time in conjuction with a receptor loading dose of the therapeutic agent
  申请人：——

  公开号：US20020034534A1

  公开（公告）日：2002-03-21

  The present invention provides systems and methods for administering a therapeutic agent to a patient in need an initial loading dose of the therapeutic agent administered in conjunction with a long-term maintenance dose of the therapeutic agent. The present invention discloses subcutaneous-implantable dosage forms capable of administering the long-term maintenance dose of the therapeutic agent in a steady state or zero order manner. Systems and methods for administering an initial loading dose of a therapeutic agent administered in conjunction with an extended release dosage form of the therapeutic agent, and optionally in conjunction with a receptor loading dose of the therapeutic agent, are useful in the treatment of various diseases and disorders.

  本发明提供了向需要治疗剂的患者施用治疗剂的系统和方法，在施用治疗剂的初始负荷剂量的同时施用治疗剂的长期维持剂量。本发明公开了能够以稳态或零阶方式给药治疗剂长期维持剂量的皮下植入剂型。与治疗剂的缓释剂型一起给药治疗剂的初始负荷剂量，以及可选地与治疗剂的受体负荷剂量一起给药治疗剂的系统和方法，在治疗各种疾病和失调中是有用的。
• SYSTEM AND METHOD FOR EXTENDED DELIVERY OF A THERAPEUTIC AGENT WITH ITS RECEPTOR LOADING DOSE
  申请人：Trident Technologies, LLC

  公开号：EP1237544A1

  公开（公告）日：2002-09-11
• US4450150A
  申请人：——

  公开号：US4450150A

  公开（公告）日：1984-05-22