4-[hydroxy-(4-chlorophenyl)methylene]-5-(4-bromophenyl)-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-[hydroxy-(4-chlorophenyl)methylene]-5-(4-bromophenyl)-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-dione
• 英文别名: 5-(4-bromophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-dione
• 化学式: C₂₇H₂₀BrClN₂O₃
• 分子量: 535.824
• InChiKey: VDCNVXPKQMYESG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  色胺 、 对溴苯甲醛 、 甲基 4-(4-氯苯基)-2,4-二羰基丁酸 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以48%的产率得到4-[hydroxy-(4-chlorophenyl)methylene]-5-(4-bromophenyl)-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-dione
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

  摘要：

  The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.

  DOI：

  10.1134/s1070363220080083

文献信息

• Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones
  作者：V. L. Gein、M. I. Kazantseva、L. I. Varkentin、T. M. Zamaraeva、A. N. Yankin、E. V. Beletskii、V. V. Novikova

  DOI：10.1134/s1070363220080083

  日期：2020.8

  The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.