α-(4-fluorophenyl)-4-piperidinemethanol hydrochloride | 38081-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-(4-fluorophenyl)-4-piperidinemethanol hydrochloride
• 英文别名: (4-Fluorophenyl)-piperidin-4-ylmethanol;hydrochloride；(4-fluorophenyl)-piperidin-4-ylmethanol;hydrochloride
• CAS: 38081-58-2
• 化学式: C₁₂H₁₆FNO*ClH
• 分子量: 245.724
• InChiKey: MVJJRAVCVSIXPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.28
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(4-氟苯(甲)酰)吡啶 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 反应 12.0h， 以97%的产率得到α-(4-fluorophenyl)-4-piperidinemethanol hydrochloride
  参考文献：
  名称：

  Controlling chemoselective transformations of 4-acylpyridines via a Pd–C catalytic hydrodechlorination–hydrogenation

  摘要：

  A novel Pd-C catalytic hydrodechlorination-hydrogenation was developed for a multi-step one-pot transformation of 4-acylpyridines. Under the selected conditions, 4-benzoylpyridines and 4-alkanoylpyridines were chemoselectively converted into the corresponding 4-benzylpiperidine hydrochlorides and alpha-alkyl-4-piperidinemethanol hydrochlorides, respectively. This catalytic method was performed simply by an addition of 1 equiv of CICH2CHCl2 to the conventional hydrogenation system and directly gave the crystalline piperidine hydrochlorides in practical quantitative yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.12.017

文献信息

• Structure activity relationships leading to the identification of the indirect activator of AMPK, R419
  作者：Simon J. Shaw、Dane A. Goff、David C. Carroll、Rajinder Singh、David J. Sweeny、Gary Park、Yonchu Jenkins、Vadim Markovtsov、Tian-Qiang Sun、Sarkiz D. Issakani、Yasumichi Hitoshi、Donald G. Payan

  DOI：10.1016/j.bmc.2022.116951

  日期：2022.10