3-(2-dimethylamino-propoxymethyl)-pyridine | 102206-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-dimethylamino-propoxymethyl)-pyridine
• 英文别名: 3-(2-Dimethylamino-propoxymethyl)-pyridin；3-((2-(Dimethylamino)propoxy)methyl)pyridine；N,N-dimethyl-1-(pyridin-3-ylmethoxy)propan-2-amine
• CAS: 102206-61-1
• 化学式: C₁₁H₁₈N₂O
• 分子量: 194.277
• InChiKey: DEFXBODZFIAWSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-吡啶甲醇 在 sodium 、 苯 作用下， 生成 3-(2-dimethylamino-propoxymethyl)-pyridine
  参考文献：
  名称：

  Vejdalek et al., Chemicke Listy, 1954, vol. 48, p. 1221,1223

  摘要：

  DOI：

文献信息

• ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
  申请人：Targacept, Inc.

  公开号：EP1212301A1

  公开（公告）日：2002-06-12
• [EN] ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS<br/>[FR] ARYLALKYLOXYALKYLAMINES ET ARYLALKYLTHIOALKYLAMINES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN TANT QU'INHIBITEURS DES RECEPTEURS CHOLINERGIQUES NICOTINIQUES
  申请人：TARGACEPT INC

  公开号：WO2001016107A1

  公开（公告）日：2001-03-08

  Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need arylalkyloxyalkylamine and arylalkylthioalkylamine compounds, including arylmethoxyalkylamines and arylmethylthioalkylamines, such as pyridylmethoxyalkylamines and pyridylmethylthio alkylamines. Exemplary compounds include methyl(3-(3-pyridylmethoxy)propyl)amine, 3-pyridyl(pyrrolidin-2-ylmethoxy)methane, methyl(1-methyl-2-(3-pyridylmethoxy)ethyl)amine, (3-((3-pyridyl)methoxy)propyl)dimethylamine, (2-((5-bromo-3-pyridyl)methoxy)ethyl)methylamine, methyl(2-((5-methoxy-3-pyridyl)methoxy)ethyl)amine, (2-((3-quinolyl)methoxy)ehtyl)methylamine, methyl(2-(pyrimidin-5-ylmethoxy)ethyl)amine, 3-((3-pyridyl)methoxy)quinuclidine, (3-pyridyl)quinuclidin-2-ylmethoxy)methane, (3-pyridyl)(pyrrolidin-2-ylmethylthio)methane and (2-((3-pyridyl)methylthio)ethyl)methylamine.
• Vejdalek et al., Chemicke Listy, 1954, vol. 48, p. 1221,1223
  作者：Vejdalek et al.

  DOI：——

  日期：——