N,N'-bis(2-bromo-4,6-dimethylphenyl)formimidamide | 1198007-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis(2-bromo-4,6-dimethylphenyl)formimidamide
• 英文别名: N,N'-bis(2-bromo-4,6-dimethylphenyl)formamidine；N,N'-bis(2-bromo-4,6-dimethylphenyl)methanimidamide
• CAS: 1198007-37-2
• 化学式: C₁₇H₁₈Br₂N₂
• 分子量: 410.151
• InChiKey: IPHPVTDQYWJZES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N'-bis(2-bromo-4,6-dimethylphenyl)formimidamide 在 copper(l) iodide 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二甲基亚砜 为溶剂， 以97%的产率得到1-(2-bromo-4,6-dimethylphenyl)-4,6-dimethyl-1H-benzimidazole
  参考文献：
  名称：

  Copper-Catalyzed Synthesis of 2-Unsubstituted, N-Substituted Benzimidazoles

  摘要：

  An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-tert-butylphenyl and tolerating various functional groups demonstrate the utility of this method.

  DOI：

  10.1021/jo902160y
• 作为产物：
  描述：

  2-溴-4,6-二甲基苯胺 、 原甲酸三乙酯 在 溶剂黄146 作用下， 反应 11.0h， 以77%的产率得到N,N'-bis(2-bromo-4,6-dimethylphenyl)formimidamide
  参考文献：
  名称：

  US2014/275555

  摘要：

  公开号：

文献信息

• Copper, Silver and Sodium Salt-Mediated Quaternization by Arylation: Syntheses of N-Heterocyclic Carbene Precursors and 6-<i>H</i>-Phenanthridine Derivatives
  作者：Wenqi Shen、Jing Li、Caiyun Zhang、Min Shi、Jun Zhang

  DOI：10.1002/asia.201600563

  日期：2016.7.5

  synthesize a variety of N‐heterocyclic carbene (NHC) precursors with a benzene‐fused backbone. The methodology also provides a convenient alternative route for the synthesis of 6‐H‐phenanthridine derivatives. A novel silver–NHC complex was prepared by treatment of Ag2O with the free carbene, which was in situ prepared from the deprotonation of a representative quinazolinonium salt.

  我们已经通过芳基化反应开发了Cu II，Ag I和NaOTf介导的分子内季铵化反应，以合成具有苯稠合骨架的各种N杂环卡宾（NHC）前体。该方法还为合成6 H-菲啶衍生物提供了便利的替代途径。通过用游离的卡宾处理Ag 2 O制备了一种新型的银-NHC络合物，该化合物是通过代表性的喹唑啉鎓盐的去质子化而原位制备的。
• US20140275555A1
  申请人：——

  公开号：US20140275555A1

  公开（公告）日：2014-09-18
• ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS
  申请人：Massachusetts Institute of Technology

  公开号：US20160355484A1

  公开（公告）日：2016-12-08

  Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.
• US9382210B2
  申请人：——

  公开号：US9382210B2

  公开（公告）日：2016-07-05
• US9815793B2
  申请人：——

  公开号：US9815793B2

  公开（公告）日：2017-11-14