o-tert-butylphenylacetone | 58443-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-tert-butylphenylacetone
• 英文别名: 1-(2-t-Butylphenyl)-2-propanon；1-(2-Tert-butylphenyl)propan-2-one
• CAS: 58443-85-9
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: PBCNZTLMNMYPOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  丙酮 、 Phosphoric acid 2-tert-butyl-phenyl ester diethyl ester 在 potassium tert-butylate 作用下， 以 氨 为溶剂， 生成 o-tert-butylphenylacetone
  参考文献：
  名称：

  Bunnett,J.F.; Sundberg,J.E., Chemical and pharmaceutical bulletin, 1975, vol. 23, p. 2620 - 2628

  摘要：

  DOI：

文献信息

• An Effective System to Synthesize Arylacetones. Substrate-ionic Liquid-ultrasonic Irradiation
  作者：Zhu Yinghuai、Stefan Bahnmueller、Narayan S. Hosmane、John A. Maguire

  DOI：10.1246/cl.2003.730

  日期：2003.8

  Manganese(III) acetate-promoted aromatic acetonylation has been accomplished with ultrasonic irradiation in ionic liquids, [N-n-pentyl-4-picolinium] [closo-CB11H12] (1), [OMIM] [BF4] and [BMIM] [PF6] in 62-93% yields, with excellent chemical selectivity.

  已在离子液体 [Nn-pentyl-4-picolinium] [closo-CB11H12] (1)、[OMIM] [BF4] 和 [BMIM] [PF6] 中通过超声波照射完成乙酸锰 (III) 促进的芳香族乙酰化以 62-93% 的收率，具有出色的化学选择性。
• COMBINATION THERAPIES FOR TREATMENT OF CANCER
  申请人：Araxes Pharma LLC

  公开号：US20160166571A1

  公开（公告）日：2016-06-16

  Combination therapies for treatment of cancers associated with mutations in the KRAS gene are provided. Compositions comprising therapeutic agents for treatment of cancers associated with mutations in the KRAS gene are also provided.

  提供了用于治疗与KRAS基因突变相关的癌症的联合治疗方案。还提供了包含治疗剂的组合物，用于治疗与KRAS基因突变相关的癌症。
• ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150307483A1

  公开（公告）日：2015-10-29

  Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

  具有以下式(I)的化合物或其立体异构体或药学上可接受的盐，其中R1、R2、R3、R4和R5的定义如本文所述，可用于调节IL-12、IL-23和/或IFNα，通过作用于Tyk-2以引起信号转导抑制。
• Catalysts comprising Copper and the use thereof in the preparation of aldehydes
  申请人：Union Camp Corporation

  公开号：EP0529804A2

  公开（公告）日：1993-03-03

  Catalysts, catalyst precursors, and catalytic systems are provided. The catalysts generally comprise a substrate that includes a group IB metal and a substantially porous, microcrystalline layer that includes the metal and that is disposed on at least a portion of the substrate. The catalysts are prepared by providing a substrate that includes group IB metal, oxidizing said substrate to produce an oxide coating of said group IB metal, and reducing substantially all of said oxidized substrate. The catalysts are useful in the preparation of aldehydes by vapor phase dehydrogenation of alcohols.

  提供催化剂、催化剂前体和催化系统。催化剂一般包括一个包含 IB 族金属的基底和一个包含该金属并设置在基底至少一部分上的多孔微晶层。催化剂的制备方法是提供包括 IB 族金属的基底，氧化所述基底以产生所述 IB 族金属的氧化物涂层，然后还原基本上所有所述氧化基底。 催化剂可用于通过醇的气相脱氢制备醛。
• Methods and compositions for inhibition of Ras
  申请人：ARAXES PHARMA LLC

  公开号：US10011600B2

  公开（公告）日：2018-07-03

  Inhibitors of Ras protein, methods to modulate the activity of Ras protein, and methods of treatment of disorders mediated by Ras protein are provided. A method for regulating activity of a K-Ras, H-Ras or N-Ras mutant protein with a compound is described. Disorders that can be treated include cancer, such as hematological cancer, pancreatic cancer, MYH associated polyposis, colorectal cancer, or lung cancer.

  提供了 Ras 蛋白的抑制剂、调节 Ras 蛋白活性的方法以及治疗由 Ras 蛋白介导的疾病的方法。描述了一种用化合物调节 K-Ras、H-Ras 或 N-Ras 突变蛋白活性的方法。可治疗的疾病包括癌症，如血癌、胰腺癌、MYH 相关性息肉病、结直肠癌或肺癌。