(E)-N-benzyl-N-(4-methylphenyl)sulfonylnon-2-enamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-benzyl-N-(4-methylphenyl)sulfonylnon-2-enamide
• 化学式: C₁₆H₂₃N₄O₄Pol
• 分子量: 399.5
• InChiKey: QBDOEDKNDRAMCF-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(9H-fluoren-9-ylmethoxycarbonyl)-6-aminohexanoic acid chloride 、 (E)-N-benzyl-N-(4-methylphenyl)sulfonylnon-2-enamide 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 9H-fluoren-9-ylmethyl N-[(4-carbonochloridoylphenyl)methyl]carbamate
  参考文献：
  名称：

  Solid-Phase Synthesis of Azidomethylene Inhibitors Targeting Cysteine Proteases

  摘要：

  An efficient strategy for the solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases is described. The method is highlighted by its compatibility with readily available building blocks, as well as its ability to accommodate different functional groups. A 249-member library has thus far been successfully synthesized, characterized, and screened against Caspase-1, -3 and -7.

  DOI：

  10.1021/ol800575z
• 作为产物：
  描述：

  N-benzyl-N-(3-hydroxy-1-nonynyl)-4-methylbenzenesulfonamide 在 bis(acetylacetonato)dioxidomolybdenum(VI) 、 [Au(Cl)PPh₃] 、 silver trifluoromethanesulfonate 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以80%的产率得到(E)-N-benzyl-N-(4-methylphenyl)sulfonylnon-2-enamide
  参考文献：
  名称：

  Mo−Au Combo Catalysis for Rapid 1,3-Rearrangement of Propargyl Alcohols into α,β-Unsaturated Carbonyl Compounds

  摘要：

  The combination of Mo and cationic Au catalysts dramatically accelerated the rearrangement of diverse propargyl alcohols, which includes a short reaction time, mild conditions, and high product yields. A practical application to the highly challenging primary propargyl alcohols and the N-alkynyl amides is achieved.

  DOI：

  10.1021/ol800596c