2-Isopropylidenetetrahydrofuran | 38614-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 英文名称: 2-Isopropylidenetetrahydrofuran
• 英文别名: 2-Isopropylidentetrahydrofuran；2-propan-2-ylideneoxolane
• CAS: 38614-14-1
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: UZXWDKGGOMPAEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(2-羟基丙烷-2-基)四氢呋喃-2-羧酸 在 氧代氯化钨 Proton Sponge 作用下， 反应 24.0h， 以27%的产率得到2-Isopropylidenetetrahydrofuran
  参考文献：
  名称：

  The preparation of (α-alkylidene)tetrahydrofurans by tungsten catalyzed decarboxylation of aldol precursors

  摘要：

  A series of substituted (alpha-alkylidene)tetrahydrofurans was prepared by tungsten catalyzed reaction of substituted hydroxyfuroic acids. These reactions likely involve beta-lactone intermediates which decarboxylate under the reaction conditions, and rates for olefin synthesis correlated with donor properties of substituents at C(4).

  DOI：

  10.1016/s0040-4039(00)61775-6

文献信息

• SULFONAMIDE DERIVATIVES AND USES THEREOF
  申请人：NodThera Limited

  公开号：US20220267300A1

  公开（公告）日：2022-08-25

  The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
• The preparation of (α-alkylidene)tetrahydrofurans by tungsten catalyzed decarboxylation of aldol precursors
  作者：Tomoya Tanzawa、Jeffrey Schwartz

  DOI：10.1016/s0040-4039(00)61775-6

  日期：1992.11

  A series of substituted (alpha-alkylidene)tetrahydrofurans was prepared by tungsten catalyzed reaction of substituted hydroxyfuroic acids. These reactions likely involve beta-lactone intermediates which decarboxylate under the reaction conditions, and rates for olefin synthesis correlated with donor properties of substituents at C(4).