6-[2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-[2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic acid
• 英文别名: 6-[2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid
• 化学式: C₂₂H₂₃ClO₅
• 分子量: 402.9
• InChiKey: WHUIENZXNGAHQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED 1,3-DIOXANES AND THEIR USES
  申请人：Evolva SA

  公开号：EP2124558A2

  公开（公告）日：2009-12-02
• SUBSTITUTED 1,3-DIOXANES USEFUL AS PPAR MODULATORS
  申请人：Evolva SA

  公开号：EP2150111A1

  公开（公告）日：2010-02-10
• 1,3-Dioxanes and Their Uses
  申请人：Sorensen Alexandra Santana

  公开号：US20120252836A1

  公开（公告）日：2012-10-04

  The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
• Substituted 1,3-Dioxanes and There Uses
  申请人：Sorensen Alexandra Santana

  公开号：US20130197030A1

  公开（公告）日：2013-08-01

  The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
• Substituted 1,3-Dioxanes Useful as PPAR Modulators
  申请人：Sorensen Alexandra Santana

  公开号：US20130267561A1

  公开（公告）日：2013-10-10

  Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.