N,1,5-三甲基-1H-吡唑-3-甲酰胺 | 136678-94-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N,1,5-三甲基-1H-吡唑-3-甲酰胺
• 英文名称: 3,5-Dimethyl-1-methylcarbamoyl-pyrazol
• 英文别名: 1,5-dimethyl-1H-pyrazole-3-carboxylic acid methylamide；N,1,5-trimethyl-1H-pyrazole-3-carboxamide；N,1,5-trimethylpyrazole-3-carboxamide
• CAS: 136678-94-9
• 化学式: C₇H₁₁N₃O
• mdl: MFCD09965499
• 分子量: 153.184
• InChiKey: VOHYIZCWGLXIRK-UHFFFAOYSA-N

物化性质

• 沸点：
  309.6±30.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• IMIDAZO[1,2-a]PYRIDINE COMPOUNDS
  申请人：Fang Qun Kevin

  公开号：US20110166146A1

  公开（公告）日：2011-07-07

  Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.

  本发明揭示了咪唑并[1,2-a]吡啶类化合物。该发明的化合物是有用的治疗剂，揭示了它们在制药配方中的包含以及在治疗方法中的使用。
• DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20140031334A1

  公开（公告）日：2014-01-30

  A heterocyclic compound or a salt thereof represented by the formula (1): where R 2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R 1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  一种由公式（1）表示的杂环化合物或其盐： 其中，R2表示氢原子或低级烷基基团；A表示低级烷基烯基基团；R1表示芳香基团或杂环基团。本发明的化合物具有广泛的治疗精神障碍，包括中枢神经系统障碍的光谱，无副作用和高安全性。
• Modulators of muscarinic receptors
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP2364705A2

  公开（公告）日：2011-09-14

  The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.

  本发明涉及毒蕈碱受体的调节剂。本发明还提供了包含此类调节剂的组合物，以及用其治疗或治疗毒蕈碱受体介导的疾病的方法。
• Indoles for use in influenza virus infection
  申请人：Janssen Sciences Ireland UC

  公开号：US10597390B2

  公开（公告）日：2020-03-24

  The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.

  本发明涉及具有式（I）结构的化合物，可用于治疗或预防流感感染。
• INDOLES FOR USE IN INFLUENZA VIRUS INFECTION
  申请人：Janssen Sciences Ireland UC

  公开号：US20170226102A1

  公开（公告）日：2017-08-10

  The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.