triallylphosphine oxide | 2946-60-3

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: triallylphosphine oxide
• 英文别名: Tris(propen-2-yl)phosphine oxide；tris(prop-2-enyl)phosphine oxide；Triallyl-phosphinoxid；Phosphine oxide, tri-2-propenyl-；3-bis(prop-2-enyl)phosphorylprop-1-ene
• CAS: 2946-60-3
• 化学式: C₉H₁₅OP
• 分子量: 170.191
• InChiKey: ZCENFMDNVIAVDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  triallylphosphine oxide 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以16%的产率得到tris(2,3-epoxypropyl)phosphine oxide
  参考文献：
  名称：

  Sosnovsky; Lukszo, European Journal of Medicinal Chemistry, 1984, vol. 19, # 4, p. 331 - 340

  摘要：

  DOI：
• 作为产物：
  描述：

  烯丙基溴化镁 在 乙醚 、 三氯氧磷 作用下， 生成 triallylphosphine oxide
  参考文献：
  名称：

  Kennedy et al., Journal of Applied Chemistry, 1958, vol. 8, p. 459,462

  摘要：

  DOI：

文献信息

• INTRACELLULAR SUBSTANCE TRANSPORT SYSTEM AND USE THEREOF
  申请人：National University Corporation Hokkaido University

  公开号：US20200138973A1

  公开（公告）日：2020-05-07

  The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B). In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S- terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.

  本发明涉及一种包括纳米粒子的复合物，所述纳米粒子表面携带有一种由通用式（A）显示的溶酶体酶抑制剂或激酶抑制剂以及一种由通用式（B）显示的磷脂类拟物物质。 在通用式（A）中，n1是2-30的整数，n2是2-30的整数，-S-端是纳米粒子携带位点，R10是自杀底物位点或激酶抑制位点。在通用式（B）中，n3是2-30范围内的整数，-S-端是纳米粒子携带位点。本发明提供了一种多功能系统，能够有效地将药物传递至内溶酶体，并使药物在低浓度下对溶酶体酶起作用，以及使用该系统的抗癌剂。
• [EN] PHOSPHINYL HYDRAZIDES<br/>[FR] HYDRAZIDES DE PHOSPHINYLE
  申请人：MERCK PATENT GMBH

  公开号：WO2011095277A1

  公开（公告）日：2011-08-11

  This invention relates to fluorinated phosphinyl hydrazides, a process for their preparation, and the use of these compounds, especially in organic synthesis.

  这项发明涉及氟代磷酰肼，其制备方法，以及这些化合物的用途，特别是在有机合成中的应用。
• [EN] LIQUID METAL SALTS<br/>[FR] SELS DE MÉTAL LIQUIDES
  申请人：UNIV LEUVEN KATH

  公开号：WO2011109878A1

  公开（公告）日：2011-09-15

  A liquid metal salt in which a metal (M) ion is surrounded by neutral ligands (L), or by a combination of neutral ligands (L) and negatively charged ligands (Y) such that the total negative charge of the total number of negatively charged ligands (Y) is smaller than the oxidation state of the metal ion so that the metal complex has an overall positive charge, with at least one counter anion (X), wherein M is a metal selected from the group consisting of copper, zinc, silver, gold, platinum, cobalt, nickel, tungsten, molybdenum and aluminium.; L is a neutral ligand and is selected from the group consisting of aceto- nitrile, propionitrile, butyronitrile, isobutyronitrile, acrylonitrile, 2-hydroxycyano-ethane, phenylacetonitrile, benzonitrile benzylnitrile, DMF, acetamide, N,N-dimethylacetamide, formamide, N-methylformamide, N-methylacetamide, DMSO, dimethylsulfone, hexa- methylphosphoramide, N-methylpyrrolidone, pyridine, morpholine, THF, diethyl ether, dimethoxyethane, bis(2-methoxyethyl) ether, triglyme, tetraglyme, pentaglyme, hexa- glyme, 1,4-dioxane, methanol, ethanol, propanol, butanol, ethyleneglycol, polyethylene- glycol, water, trialkylphosphine oxides, triaryl-phosphine oxides, trialkylphosphate, pyrazole, 3-alkylpyrazoles, 5-alkylpyrazoles, 3,5-dimethylpyrazole, imidazole, 1-alkyl- imidazoles, 1,2-dimethylimidazole, 2-imidazolid-inone, thiabendazole, ammonia, tetramethylenesulfoxide, urea, Ν,Ν,Ν',Ν'-tetramethylurea, thiourea, lactams, hydroxypyridines, 2-pyridone, pyridine-N-oxide, picoline-N-oxide, 2,6-lutidine, 2,6- lutidine N-oxide, pyrazine, pyrazine-N-oxide, 1,4-dithiane monosulfoxide, 2,2'-bipyridine, 1,10-phenanthroline, 2,6,2', 2"-terpyridine, ethylenediamine, diethyl enetriamine, 1,2,3- triaminopropane, cyclam, crown ethers and thiacrown ethers; Y is selected from the group consisting of chloride, bromide, iodide, thiocyanate, formate, acetate, trifluoroacetate, propionate, butyrate, pentanoate, hexanoate, benzoate, glycolate, heptafluorobutanate, alkylsulfate, octylsulfate, dodecylsulfate, triflate, methanesulfonate, nitrate, dicyanamide, tricyano-methanide, bis(trifluoromethylsulfonyl)-imide or bis(perfluoroalkylsulfonyl)- imide, dimethylphosphate, diethylphosphate, dialkylphosphate, saccharinate, acesulfamate and tosylate; and X is a counter anion selected from the group consisting of hexafluoro- phosphate, tetrafluoroborate, bis(trifluoromethylsulfonyl)imide (bistriflimide), bis(tri- fluoroalkylsulfonyl)imide, dicyanamide, triflate, methanesulfonate and trifluoroacetate; and uses thereof in an electrodeposition process, for electrodeposition of a metal M, for battery application; for electrochromic device, in fuel cells, for electropolishing and for electroless deposition of a metal M.

  一种液态金属盐，其中金属（M）离子被中性配体（L）包围，或者被中性配体（L）和带负电荷的配体（Y）的组合包围，以使得带负电荷的配体（Y）的总数的总负电荷小于金属离子的氧化态，从而使金属配合物具有整体正电荷，至少有一个对应阴离子（X），其中M是从铜、锌、银、金、铂、钴、镍、钨、钼和铝组成的金属中选择的；L是中性配体，从乙腈、丙腈、丁腈、异丁腈、丙烯腈、2-羟基氰乙烷、苯乙腈、苯甲腈、二甲甲酰胺、乙酰胺、N，N-二甲基乙酰胺、甲酰胺、N-甲基甲酰胺、N-甲基乙酰胺、二甲基亚砜、二甲基亚砜、六甲基磷酰胺、N-甲基吡咯烷酮、吡啶、吗啉、THF、乙醚、二甲氧基乙烷、双（2-甲氧基乙基）醚、三甘醇醚、四甘醇醚、五甘醇醚、六甘醇醚、1,4-二氧杂环己烷、甲醇、乙醇、丙醇、丁醇、乙二醇、聚乙二醇、水、三烷基膦氧化物、三芳基膦氧化物、三烷基磷酸酯、吡唑、3-烷基吡唑、5-烷基吡唑、3,5-二甲基吡唑、咪唑、1-烷基咪唑、1,2-二甲基咪唑、2-咪唑烷酮、噻苯唑、氨、四亚甲基亚砜、尿素、N，N，N'，N'-四甲基尿素、硫脲、内酰胺、羟基吡啶、2-吡啶酮、吡啶-N-氧化物、吡啶-N-氧化物、2,6-吡啶、2,6-吡啶-N-氧化物、吡嗪、吡嗪-N-氧化物、1,4-二硫代环己烷一氧化物、2,2'-联吡啶、1,10-邻菲啰啉、2,6,2'，2"-三吡啶、乙二胺、二乙烯三胺、1,2,3-三氨基丙烷、环戊胺、冠醚和硫冠醚中选择；Y从氯化物、溴化物、碘化物、硫氰酸盐、甲酸盐、乙酸盐、三氟乙酸盐、丙酸盐、丁酸盐、戊酸盐、己酸盐、苯甲酸盐、乙二醇酸盐、康酸盐、庚氟丁酸盐、烷基硫酸盐、辛基硫酸盐、十二烷基硫酸盐、三氟甲磺酸盐、甲磺酸盐、硝酸盐、二氰胺盐、三氰甲烷盐、双（三氟甲基磺酰）亚胺或双（全氟烷基磺酰）亚胺、二甲基磷酸盐、二乙基磷酸盐、二烷基磷酸盐、糖精盐、阿斯巴甜和对甲苯磺酸盐中选择；X是从六氟磷酸盐、四氟硼酸盐、双（三氟甲基磺酰）亚胺（双三氟甲基亚砜）, 双（三氟烷基磺酰）亚胺, 二氰胺盐, 三氟甲磺酸盐, 甲磺酸盐和三氟乙酸盐组成的对应阴离子中选择；以及在电沉积过程中的用途，用于金属M的电沉积，用于电池应用；用于电致变色器件，在燃料电池中，用于电解抛光和金属M的无电镀。
• Novel phosphonium salt ionic liquid and reaction solvent including the same
  申请人：Tsunashima Katsuhiko

  公开号：US20080221353A1

  公开（公告）日：2008-09-11

  The present invention provides an ionic liquid including a quaternary phosphonium salt represented by general formula (1): wherein R 1 , R 2 , R 3 , and R 4 each represent a linear alkyl group having 1 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms, an alicyclic alkyl group having 3 to 6 carbon atoms, or an alkoxyalkyl group represented by —(CH 2 ) n O—R 5 (wherein n is an integer of 1 to 6; and R 5 represents a methyl group or an ethyl group); at least one of R 1 , R 2 , R 3 , and R 4 is an alkoxyalkyl group; R 1 , R 2 , R 3 , and R 4 may be the same or different; R 1 and R 2 together may form a ring; and X represents an anion. The present invention also provides a reaction solvent including the ionic liquid.

  本发明提供了一种离子液体，包括由通用式（1）表示的季铵磷酸盐，其中R1、R2、R3和R4分别代表具有1至6个碳原子的直链烷基基团、具有3至6个碳原子的支链烷基基团、具有3至6个碳原子的脂环烷基基团，或者由—(CH2)nO—R5表示的烷氧基烷基基团（其中n为1至6的整数；R5代表甲基基团或乙基基团）；R1、R2、R3和R4中至少有一个是烷氧基烷基基团；R1、R2、R3和R4可以相同也可以不同；R1和R2可以共同形成一个环；X代表阴离子。本发明还提供了一种包括该离子液体的反应溶剂。
• Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
  申请人：Wei Edward T.

  公开号：US20150164924A1

  公开（公告）日：2015-06-18

  The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-isopropyl-phosphinoyl-alkanes as described herein, DIPA-1-5, DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”, that are useful, for example, in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by irritation, itch, or pain); a skin dysesthesia; dermatitis; ocular pain and discomfort; heat discomfort; heat stress; flushing and/or night sweats (vasomotor symptoms); post-operative hypothermia; post-anaesthetic shivering; fatigue; tiredness; depression; cognitive dysfunction; and to enhance cognitive function. The applicant has found that localized delivery of DIPA compounds to the upper eyelid and/or facial skin has an alerting and enhancement effect on behavior and can be used to give a cosmetic refreshing look, to mental alertness, to reduce fatigue, and to improve work output. The present discovery also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy, in diagnosis of neuropathic pain, and in study of TRPM8 function.

  本发现通常涉及治疗化合物领域。更具体地，本发现涉及如下所述的某些二异丙基磷酰基烷烃，即DIPA-1-5、DIPA-1-6、DIPA-1-7、DIPA-1-8和DIPA-1-9，以下统称为“DIPA化合物”，这些化合物在治疗包括但不限于感觉不适（例如由刺激、瘙痒或疼痛引起）、皮肤感觉异常、皮炎、眼部疼痛和不适、热感不适、热应激、潮红和/或盗汗（血管运动症状）、术后低体温、麻醉后颤抖、疲劳、疲倦、抑郁、认知功能障碍以及增强认知功能等疾病（例如疾病）的治疗中具有用途。申请人发现将DIPA化合物局部传递至上眼睑和/或面部皮肤对行为具有警觉和增强效果，并可用于给予一种化妆上的焕然一新的外观，提高精神警觉度，减轻疲劳，并提高工作产出。本发现还涉及包含此类化合物的药物组合物，以及此类化合物和组合物的用途，例如在治疗、神经病痛诊断和TRPM8功能研究中的应用。