N-(4-Chloro-phenyl)-N'-eth-(E)-ylidene-hydrazine | 56188-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Chloro-phenyl)-N'-eth-(E)-ylidene-hydrazine
• 英文别名: Rfvjrpoxeqzkha-wtdswwltsa-；4-chloro-N-[(E)-ethylideneamino]aniline
• CAS: 56188-48-8
• 化学式: C₈H₉ClN₂
• 分子量: 168.626
• InChiKey: RFVJRPOXEQZKHA-WTDSWWLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-Chloro-phenyl)-N'-eth-(E)-ylidene-hydrazine 在 吡啶 、 盐酸 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 2.67h， 生成 4-Butoxy-benzoic acid N-(4-chloro-phenyl)-hydrazide
  参考文献：
  名称：

  Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead

  摘要：

  A series of N-(p-alkoxy)benzoyl-5-methoxy-2-methylindole-3-acetic acids and N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid were discovered as new chemical leads for a prostaglandin D-2 (PGD(2)) receptor antagonist. Most of them exhibited PGD(2) receptor binding and blocked cyclic adenosine 3',5'-monophosphate (cAMP) formation in vitro. In particular, 2-methylindole-4-acetic acid analog 1 showed markedly increased receptor affinity and cAMP antagonist activity. Chemistry and structure activity relationship (SAR) data are also presented. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.11.011
• 作为产物：
  描述：

  乙醛 、 4-氯苯肼 以 甲苯 为溶剂， 反应 2.0h， 生成 N-(4-Chloro-phenyl)-N'-eth-(E)-ylidene-hydrazine
  参考文献：
  名称：

  Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead

  摘要：

  A series of N-(p-alkoxy)benzoyl-5-methoxy-2-methylindole-3-acetic acids and N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid were discovered as new chemical leads for a prostaglandin D-2 (PGD(2)) receptor antagonist. Most of them exhibited PGD(2) receptor binding and blocked cyclic adenosine 3',5'-monophosphate (cAMP) formation in vitro. In particular, 2-methylindole-4-acetic acid analog 1 showed markedly increased receptor affinity and cAMP antagonist activity. Chemistry and structure activity relationship (SAR) data are also presented. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.11.011

文献信息

• 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1555267B1

  公开（公告）日：2013-01-16
• Azole compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0567982B1

  公开（公告）日：1998-07-01
• Schantl Joachim G., Kaehlig Hanspeter, Prean Michael, Heterocycles, 37 (1994) N 3, S 1873-1878
  作者：Schantl Joachim G., Kaehlig Hanspeter, Prean Michael

  DOI：——

  日期：——
• BOKIJ N. G.; BABUSHKINA T. A.; VASILEV A. M.; VOLODINA T. A.; KOZIK T. A.+, ZH. ORGAN. XIMII <ZORK-AE>, 1975, 11, HO 5, 996-1000
  作者：BOKIJ N. G.、 BABUSHKINA T. A.、 VASILEV A. M.、 VOLODINA T. A.、 KOZIK T. A.+

  DOI：——

  日期：——
• US5371101A
  申请人：——

  公开号：US5371101A

  公开（公告）日：1994-12-06