4-(6-cyanopyridin-2-yl)benzoic acid methyl ester | 296776-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(6-cyanopyridin-2-yl)benzoic acid methyl ester
• 英文别名: Methyl 4-(6-cyanopyridin-2-yl)benzoate；methyl 4-(6-cyanopyridin-2-yl)benzoate
• CAS: 296776-88-0
• 化学式: C₁₄H₁₀N₂O₂
• 分子量: 238.246
• InChiKey: GEWNONHANMRTDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对溴苯甲酸甲酯 、 2-氯-6-氰基吡啶 在 (2,2'-bipyridine)nickel(II) dibromide tetrabutylammonium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以59%的产率得到4-(6-cyanopyridin-2-yl)benzoic acid methyl ester
  参考文献：
  名称：

  Electrosynthesis of functionalized 2-arylpyridines from functionalized aryl and pyridine halides catalyzed by nickel bromide 2,2′-bipyridine complex

  摘要：

  2-Arylpyridines substituted on aryl and/or on pyridine nuclei can be obtained in good to high yields in one step by electroreduction of mixtures of the corresponding aryl and pyridyl halides using the sacrificial iron anode process and a nickel 2,2'-bipyridine complex catalyst in DMF as solvent. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00760-7

文献信息

• Electrosynthesis of functionalized 2-arylpyridines from functionalized aryl and pyridine halides catalyzed by nickel bromide 2,2′-bipyridine complex
  作者：Corinne Gosmini、Jean Yves Nédélec、Jacques Périchon

  DOI：10.1016/s0040-4039(00)00760-7

  日期：2000.6

  2-Arylpyridines substituted on aryl and/or on pyridine nuclei can be obtained in good to high yields in one step by electroreduction of mixtures of the corresponding aryl and pyridyl halides using the sacrificial iron anode process and a nickel 2,2'-bipyridine complex catalyst in DMF as solvent. (C) 2000 Elsevier Science Ltd. All rights reserved.