5-(Dipentylamino)-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(Dipentylamino)-5-oxopentanoic acid
• 化学式: C₁₅H₂₉NO₃
• mdl: MFCD01346267
• 分子量: 271.4
• InChiKey: VWOZTYAWDCUDEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.866
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Amino acid analogs as CCK-antagonists
  申请人：Merck & Co., Inc.

  公开号：EP0250148A2

  公开（公告）日：1987-12-23

  Analogs of glutamic acid and related amino acids and pharmaceutically-acceptable salts thereof which antagonize the function of cholecystokinins and gastrin disease states in animals and compositions for and methods of preventing or treating disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals, especially of humans.

  谷氨酸和相关氨基酸的类似物及其药学上可接受的盐，可拮抗动物体内胆囊收缩素的功能和胃泌素疾病状态，以及用于预防或治疗哺乳动物，尤其是人类的胃肠道、中枢神经和食欲调节系统疾病的组合物和方法。
• Method and means for inducing constriction of the pupil in the eye
  申请人：Kabi Pharmacia AB

  公开号：EP0522596A1

  公开（公告）日：1993-01-13

  The use of cholecystokinin and derivatives of cholecystokinin for inducing miosis in the eye (pupil constriction) after certain types of examinations and operations. The invention moreover also comprises ophthalmological compositions containing an active amount of cholecystokinin or of its derivatives.

  胆囊收缩素和胆囊收缩素衍生物用于在某些类型的检查和手术后诱导眼球收缩（瞳孔收缩）。此外，本发明还包括含有活性量胆囊收缩素或其衍生物的眼科组合物。
• METHOD AND MEANS FOR INDUCING, RESP., PREVENTING CONSTRICTION OF THE PUPIL IN THE EYE
  申请人：PHARMACIA AB

  公开号：EP0422181A1

  公开（公告）日：1991-04-17
• [EN] METHOD AND MEANS FOR INDUCING, RESP., PREVENTING CONSTRICTION OF THE PUPIL IN THE EYE
  申请人：PHARMACIA AB

  公开号：WO1990011773A1

  公开（公告）日：1990-10-18

  (EN) The use of cholecystokinin and derivatives of cholecystokinin for inducing miosis in the eye (pupil constriction) $i(after) certain types of examinations and operations. Furthermore, the use of antagonists to cholecystokinin and derivatives of these for preventing miosis in the eye, for example $i(during) surgery and in cases of uveitis. The invention moreover also comprises ophthalmological compositions containing an active amount of cholecystokinin or of its derivatives or antagonists.(FR) Utilisation de cholécystokinine et dérivés de cholécystokinine pour induire le myosis (constriction de la pupille) $i(après) certains examens et opérations. En outre, l'utilisation d'antagonistes à la cholécystokinine et leurs dérivés pour empêcher le myosis par exemple $i(pendant) la chirurgie, et dans des cas d'uvéite. Ladite invention comprend d'ailleurs des compositions ophtalmologiques contenant une quantité active de cholécystokinine ou de ses dérivés ou antagonistes.