[5-[Bis(4-methoxy-3,5-dimethylphenyl)phosphanylmethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-bis(4-methoxy-3,5-dimethylphenyl)phosphane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [5-[Bis(4-methoxy-3,5-dimethylphenyl)phosphanylmethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-bis(4-methoxy-3,5-dimethylphenyl)phosphane
• 化学式: C₄₃H₅₆O₆P₂
• 分子量: 730.8
• InChiKey: SKXXXRFPVHLNLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] HYDROFORMYLATION PROCESS<br/>[FR] PROCÉDÉ D'HYDROFORMYLATION
  申请人：LYONDELL CHEMICAL TECH LP

  公开号：WO2010132087A1

  公开（公告）日：2010-11-18

  A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst comprising a rhodium complex and a diphosphine. The diphoshine is a trans-1,2-bis(bis(3,4-di-n-alkylphenyl)phosphinomethyl)cyclobutane and/or a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,4-di-n-alkylphenyl)phosphino] butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.

  本发明涉及一种生产4-羟基丁醛的方法。该方法包括在溶剂和催化剂的存在下，将丙烯醇与一种一氧化碳和氢气的混合物反应，所述催化剂包括一个铑配合物和一个二膦。所述二膦是一种trans-1,2-双[双(3,4-二-n-烷基苯基)膦甲基]环丁烷和/或2,3-O-异丙亚甲基-2,3-双羟基-1,4-双[双(3,4-二-n-烷基苯基)膦基]丁烷。与3-羟基-2-甲基丙醛相比，该方法可高产4-羟基丁醛。
• Pde IV inhibitors
  申请人：——

  公开号：US20040176365A1

  公开（公告）日：2004-09-09

  The purpose is to provide selective PDE IV inhibitors which have a potent anti-asthmatic profile with excellent safety. A compound of the formula (1): 1 wherein A is methylene, lower alkylmethylene, carbonyl, etc., Y is a 5- or 6-membered heteroaryl group containing one or two heteroatoms selected from nitrogen, sulfur and oxygen, Z is i) a fused ring in which any of 5- or 6-membered heteroaryl groups is fused to a benzene ring, or ii) a phenyl group which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of nitro, amino, an amino nitrogen-containing group, etc., provided that when A is methylene, Y is a 5- or 6-membered heteroaryl group selected from the group consisting of pyrrolyl, pyridyl, etc., and Z is a phenyl group which may be unsubstituted or substituted, the substituent on said phenyl group is amino, or an amino nitrogen-containing group; or a pharmaceutically acceptable salt thereof, possesses excellent PDE IV inhibition and is useful as a pharmaceutical drug, preferably an anti-asthmatic, etc.

  这段话的目的是提供具有强效抗哮喘特性和优异安全性的选择性PDE IV抑制剂。式(1)的化合物：其中A是亚甲基，低碳基亚甲基，羰基等，Y是含有氮、硫和氧中的一种或两种杂原子的5-或6成员杂芳基团，Z是i）融合环，其中任何5-或6成员杂芳基团融合到苯环中，或ii）苯基，可以是未取代或可选地取代一个或多个来自硝基，氨基，含氨基氮的基团等的成员，但当A是亚甲基时，Y是从吡咯基，吡啶基等中选择的5-或6成员杂芳基团，Z是未取代或取代的苯基时，所述苯基上的取代基是氨基或含氨基氮的基团；或其药学上可接受的盐，具有优异的PDE IV抑制作用，是一种有用的药物，首选是抗哮喘药物等。
• PDE IV INHIBITORS
  申请人：Grelan Pharmaceutical Co., Ltd.

  公开号：EP1403270A1

  公开（公告）日：2004-03-31

  The purpose is to provide selective PDE IV inhibitors which have a potent anti-asthmatic profile with excellent safety. A compound of the formula (1): wherein A is methylene, lower alkylmethylene, carbonyl, etc., Y is a 5- or 6-membered heteroaryl group containing one or two heteroatoms selected from nitrogen, sulfur and oxygen, Z is i) a fused ring in which any of 5- or 6-membered heteroaryl groups is fused to a benzene ring, or ii) a phenyl group which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of nitro, amino, an amino nitrogen-containing group, etc., provided that when A is methylene, Y is a 5- or 6-membered heteroaryl group selected from the group consisting of pyrrolyl, pyridyl, etc., and Z is a phenyl group which may be unsubstituted or substituted, the substituent on said phenyl group is amino, or an amino nitrogen-containing group; or a pharmaceutically acceptable salt thereof, possesses excellent PDE IV inhibition and is useful as a pharmaceutical drug, preferably an anti-asthmatic, etc.

  目的是提供选择性 PDE IV 抑制剂，这种抑制剂具有强效的抗哮喘特性和极佳的安全性。一种式（1）的化合物： 其中 A 是亚甲基、低级烷基亚甲基、羰基等；Y 是 5 或 6 元杂芳基，含有一个或两个选自氮、硫和氧的杂原子；Z 是 i) 融合环，其中任何 5 或 6 元杂芳基与苯环融合；或 ii) 苯基，可以是未取代的，也可以是被一个或多个选自硝基、氨基、含氮氨基等组成的组的成员任选取代的、条件是当 A 为亚甲基，Y 为选自吡咯基、吡啶基等组成的组的 5 或 6 元杂芳基，Z 为未取代或取代的苯基时，所述苯基上的取代基为氨基或含氮氨基；或其药学上可接受的盐，具有优异的 PDE IV 抑制作用，可用作药物，最好是抗哮喘药物等。
• HYDROFORMYLATION PROCESS
  申请人：Lyondell Chemical Technology, L.P.

  公开号：EP2081882B1

  公开（公告）日：2012-07-25
• Hydroformylation process
  申请人：White Daniel F.

  公开号：US20100292514A1

  公开（公告）日：2010-11-18

  A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst comprising a rhodium complex and a diphosphine. The diphoshine is a trans-1,2 -bis(bis(3,4-di-n-alkylphenyl)phosphinomethyl)cyclobutane and/or a 2,3-O-isopropylidene- 2,3 -dihydroxy-1,4-bis[bis(3,4-di-n-alkylphenyl)phosphino]butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.