2-[(4-Fluorophenyl)methylazaniumyl]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(4-Fluorophenyl)methylazaniumyl]acetate
• 化学式: C9H10FNO2
• mdl: MFCD03450357
• 分子量: 183.18
• InChiKey: NWZUJCANYJTQFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] TRIAZINES DERIVATIVES AS CELL ADHESION INHIBITORS<br/>[FR] DERIVES DE TRIAZINES COMME INHIBITEURS DE L'ADHESION CELLULAIRE
  申请人：RANBAXY LAB LTD

  公开号：WO2005030735A1

  公开（公告）日：2005-04-07

  The present invention relates to triazine derivatives as cell adhesion inhibitors. The compounds of this invention can be useful inter alia, for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis. The compounds can be used to formulate pharmacological compositions, and the methods of treating bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided herein.

  本发明涉及三嗪衍生物作为细胞黏附抑制剂。本发明的化合物可以用于抑制和预防细胞黏附和细胞黏附介导的病理反应，包括支气管哮喘、类风湿性关节炎、1型糖尿病、多发性硬化症、移植排斥、牛皮癣等炎性和自身免疫性疾病。这些化合物可以用于制备药物组合物，并且本文还提供了使用这些化合物治疗支气管哮喘、类风湿性关节炎、多发性硬化症、1型糖尿病、牛皮癣、移植排斥和其他炎性和/或自身免疫性疾病的方法。
• Triazines derivatives as cell adhesion inhibitors
  申请人：Sattigeri J. Viswajanani

  公开号：US20060004005A1

  公开（公告）日：2006-01-05

  The present invention relates to triazine derivatives as cell adhesion inhibitors. The compounds of this invention can be useful inter alia, for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis. The compounds can be used to formulate pharmacological compositions, and the methods of treating bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided herein.

  本发明涉及三嗪衍生物作为细胞黏附抑制剂。本发明的化合物可以用于抑制和预防细胞黏附和细胞黏附介导的病理反应，包括炎症和自身免疫性疾病，如支气管哮喘、类风湿性关节炎、1型糖尿病、多发性硬化症、同种移植排斥反应、牛皮癣等。这些化合物可以用于制备药物组合物，本文还提供了使用这些化合物治疗支气管哮喘、类风湿性关节炎、多发性硬化症、1型糖尿病、牛皮癣、同种移植排斥反应和其他炎症和/或自身免疫性疾病的方法。
• Pre-organized tricyclic integrase inhibitor compounds
  申请人：Chen James M.

  公开号：US20090029939A1

  公开（公告）日：2009-01-29

  Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A 1 and A 2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl, Q is N, + NR, or CR 4 . The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.

  本发明揭示了以下结构的三环化合物、其保护中间体以及抑制HIV整合酶的方法。其中，A1和A2是形成五、六或七元环的基团。L是连接Ar环原子和N的键或连接剂。X是O、S或取代的氮。Ar是芳基或杂环芳基，Q是N、+NR或CR4。芳基碳可以独立地被取代为除氢以外的取代基。这些化合物可以包括共价连接在任何位置的前药基团。
• Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds
  申请人：Cai R. Zhenhong

  公开号：US20080076738A1

  公开（公告）日：2008-03-27

  Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.

  本发明公开了至少具有一个膦酸酯基团的新型HIV整合酶抑制剂化合物、其受保护的中间体以及用于抑制HIV整合酶的方法。
• Novel compounds
  申请人：Ferring BV

  公开号：EP2626364A1

  公开（公告）日：2013-08-14

  The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia compromised lactation conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.

  本发明涉及新型化合物、包含上述化合物的药物组合物、使用上述化合物制造用于治疗泌乳受损等疾病的药物以及治疗上述疾病的方法，其中施用了上述化合物。这些化合物由通式 (I) 表示，如说明书中进一步定义的。