N,N'-二甲基琥珀酰胺 | 16873-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N,N'-二甲基琥珀酰胺
• 英文名称: N,N'-dimethylsuccinamide
• 英文别名: N,N'-dimethylbutanediamide；N,N'-Dimethyl-succinamid；Bernsteinsaeure-bis-methylamid；N.N'-Dimethyl-bernsteinsaeure-diamid；Methyl-malonsaeure-N,N-dimethyldiamid
• CAS: 16873-50-0
• 化学式: C₆H₁₂N₂O₂
• mdl: MFCD00085642
• 分子量: 144.173
• InChiKey: ZLBXNYLVDYFZAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

SDS

Version 1.0
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name N,N'-DIMETHYLSUCCINAMIDE - 250 MG

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2 - Hazards Identification

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
N,N'-DIMETHYLSUCCINAMIDE 16873-50-0 None None
Formula C6H12N2O2
Molecular Weight 144,1700 AMU
Synonyms RCL Substance

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4 - First Aid Measures

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AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

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5 - Fire Fighting Measures

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EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
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appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

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6 - Accidental Release Measures

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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
ADDITIONAL INFORMATION
Avoid contact with eyes, skin, and clothing.

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7 - Handling and Storage

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HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.

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8 - Exposure Controls / Personal Protection

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ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Respiratory protection is not required. Where
protection from nuisance levels of dusts are desired, use type N95
(US) or type P1 (EN 143) dust masks.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.

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9 - Physical and Chemical Properties

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Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
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Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient Log Kow: - 0,878.
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

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11 - Toxicological Information

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SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
S-PHRASES: 22
Do not breathe dust.
Caution: Substance not yet fully tested (EU).

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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反应信息

• 作为反应物：
  描述：

  N,N'-二甲基琥珀酰胺 在 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 为溶剂， 生成 N,N'-二甲基-1,4-丁二胺
  参考文献：
  名称：

  Ripperger,H., Zeitschrift fur Chemie, 1970, vol. 10, p. 141

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-己二酮 在 sodium azide 、 硫酸 作用下， 生成 N,N'-二甲基琥珀酰胺
  参考文献：
  名称：

  Caronna, Gazzetta Chimica Italiana, 1950, vol. 80, p. 675,676

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF APOL1 AND USE OF THE SAME<br/>[FR] INHIBITEURS D'APOL1 ET LEUR UTILISATION
  申请人：VERTEX PHARMA

  公开号：WO2021252859A1

  公开（公告）日：2021-12-16

  The disclosure provides at least one compound, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of formula (I), deuterated derivatives thereof, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease.

  本公开提供了至少一种化合物、重氢化衍生物或药用可接受的盐，选自公式(I)化合物、其重氢化衍生物以及任何前述物质的药用可接受的盐，包含同一的组成物，以及制造和使用同一的方法，包括用于治疗APOL1介导的肾脏疾病。
• Radical production evidenced by dimer analysis in γ-irradiated amides in aqueous solutions and in the solid state
  作者：Anne-Catherine Dusaucy、Joëlle de Doncker、Christine Couillard、Marc de Laet、Bernard Tilquin

  DOI：10.1039/f19878300125

  日期：——

  formation. In the solid state the radiolytic formation of radicals is selective. Final product analysis by capillary gas chromatography and the direct study of radicals by pulse radiolysis are also complementary methods for studying the nature of radicals produced from the radiolysis of amides in aqueous solutions. The selective production of one parent radical is characteristic of dilute solutions.

  通过两种互补的方法，对酰胺固态分解产生的自由基的性质和分布进行了研究：（i）通过毛细管气相色谱分析最终产物，以及（ii）通过电子自旋共振直接观察自由基光谱学。为二聚物的异构体分布Ñ -methylformamide（NMF），Ñ甲基乙酰胺（NMA）和Ñ，Ñ-二甲基甲酰胺（DMF）允许人们通过使用二聚体形成的统计规则来估计母体自由基的分布。在固态中，自由基的辐射分解形成是选择性的。通过毛细管气相色谱法进行最终产物分析以及通过脉冲辐射分解直接研究自由基也是研究由酰胺在水溶液中辐射分解产生的自由基的性质的补充方法。选择性产生一个母体基团是稀溶液的特征。
• 1,4-dihydropyridine compounds as bradykinin antagonists
  申请人：——

  公开号：US20020161006A1

  公开（公告）日：2002-10-31

  The present invention relates to compounds of the formula 1 wherein each A is independently halo; Y is —(CH 2 ) m —, —C(O)— or —S(O)—; R 1 and R 2 are independently C 1-4 alkyl; R 3 is substituted azacycloalkyl etc.; R 4 is phenyl substituted at the 2-position with a substituent selected from substituted C 1-7 alkyl, substituted C 1-7 alkoxy, amine, etc; R 5 is hydrogen or C 1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.

  本发明涉及公式1的化合物，其中每个A独立地是卤素；Y是—（CH2）m—，—C（O）—或—S（O）—；R1和R2独立地是C1-4烷基；R3是取代的氮杂环烷基等；R4是苯基，在2位被取代，取代基为取代的C1-7烷基，取代的C1-7烷氧基，胺等；R5是氢或C1-4烷基；m为0、1或2；n为0、1、2、3、4或5。本发明还涉及包含这些化合物的制药组合物以及在治疗和预防炎症、哮喘、过敏性鼻炎、疼痛和其他疾病中使用这些化合物的用途。
• Heterocyclic compounds having inhibitory activity against HIV integrase
  申请人：Murai Hitoshi

  公开号：US20090118233A1

  公开（公告）日：2009-05-07

  A heterocyclic compound of the formula (I): wherein B 1 is —C(R 2 )═ or —N═; R 1′ is H, etc.; one of R 1 and R 2 is -Z 1 -Z 2 -Z 3 -R 5 wherein Z 1 and Z 3 are independently single bond, optionally substituted alkylene, etc.; Z 2 is single bond, optionally substituted alkylene, etc.; R 5 is optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of R 1 and R 2 is H; -A 1 - is —C(—Y)═C(—R A )—C(—R 3 )═C(—R 4 )—, etc. wherein Y is OH, etc.; R A is —COR 7 wherein R 7 is OH, etc.; one of R 3 and R 4 is carboxy, etc., and the other of R 1 and R 2 is H, etc, a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.

  一种具有以下式（I）的杂环化合物：其中B1为—C（R2）═或—N═；R1'为H等；R1和R2中的一个为-Z1-Z2-Z3-R5，其中Z1和Z3分别为单键，可选择性地取代的烷基等；Z2为单键，可选择性地取代的烷基等；R5为可选择性取代的芳基，可选择性取代的杂环芳基等；R1和R2中的另一个为H；-A1-为—C（—Y）═C（—RA）—C（—R3）═C（—R4）—等，其中Y为OH等；RA为—COR7，其中R7为OH等；R3和R4中的一个为羧基等，另一个为H等。该化合物的前药、其药学上可接受的盐和溶剂化物具有抗病毒活性，尤其是对HIV整合酶的抑制活性，并且包含该化合物的药物组合物，特别是一种抗HIV药物。
• Organic Compounds
  申请人：Fairhurst Robin Alec

  公开号：US20100190784A1

  公开（公告）日：2010-07-29

  A compound of formula (I), or stereoisomers or pharmaceutically acceptable salts thereof, wherein, R 1a , R 1b , R 2a , R 2b , U 1 , U 2 , X 1 , X 2 and L are as defined herein.

  化合物的式子（I），或其立体异构体或药学上可接受的盐，其中，R1a，R1b，R2a，R2b，U1，U2，X1，X2和L的定义如下。

表征谱图