methyl 3-hydroxy-2-(hydroxymethyl)-2-methyl-3-phenylpropanoate | 1373819-82-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-hydroxy-2-(hydroxymethyl)-2-methyl-3-phenylpropanoate
• 英文别名: Methyl 3-hydroxy-2-(hydroxymethyl)-2-methyl-3-phenylpropanoate
• CAS: 1373819-82-9
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: GBLKVELCFFFYPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲醛 在 sodium perborate 、 CuF(PPh₃)₃*2MeOH 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 19.0h， 生成 methyl 3-hydroxy-2-(hydroxymethyl)-2-methyl-3-phenylpropanoate
  参考文献：
  名称：

  Copper catalyzed tandem conjugated borylation–aldol reaction

  摘要：

  We investigated the tandem conjugated borylation-aldol reaction catalyzed by copper complexes. After identification and optimisation of the catalytic system, the scope of the reaction was evaluated and the diastereoselectivity was studied on both linear and cyclic activated alkenes. Finally, the use of some selected borylated aldol adducts in two classical transformations was investigated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.062

文献信息

• Copper catalyzed tandem conjugated borylation–aldol reaction
  作者：Alexandre Welle、Virginie Cirriez、Olivier Riant

  DOI：10.1016/j.tet.2011.07.062

  日期：2012.4

  We investigated the tandem conjugated borylation-aldol reaction catalyzed by copper complexes. After identification and optimisation of the catalytic system, the scope of the reaction was evaluated and the diastereoselectivity was studied on both linear and cyclic activated alkenes. Finally, the use of some selected borylated aldol adducts in two classical transformations was investigated. (C) 2012 Elsevier Ltd. All rights reserved.